gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes肠道微生物宏基因组分析显示功能模型的发展为1型糖尿病自身免疫.pdfVIP

Gut Microbiome Metagenomics Analysis Suggests a Functional Model for the Development of Autoimmunity for Type 1 Diabetes 1 1 1 1 1 Christopher T. Brown , Austin G. Davis-Richardson , Adriana Giongo , Kelsey A. Gano , David B. Crabb , 2 2 1 3 4 ¨ 5 Nabanita Mukherjee , George Casella , Jennifer C. Drew , Jorma Ilonen , Mikael Knip , Heikki Hyoty , 6 7 7 8 9 8 Riitta Veijola , Tuula Simell , Olli Simell , Josef Neu , Clive H. Wasserfall , Desmond Schatz , Mark A. 9 1 Atkinson , Eric W. Triplett * 1 Department of Microbiology and Cell Science, University of Florida, Gainesville, Florida, United States of America, 2 Department of Statistics, University of Florida, Gainesville, Florida, United States of America, 3 Department of Clinical Microbiology, University of Kuopio, Kuopio, Finland, 4 Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland, 5 Department of Virology, Tampere University Hospital, Tampere, Finland, 6 Department of Pediatrics, University of Oulu, Oulu, Finland, 7 Department of Pediatrics, Turku University Hospital, Turku, Finland, 8 Department of Pediatrics, University of Florida, Gainesville, Florida, United States of America, 9 Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, Florida, United States of America Abstract Recent studies have suggested a bacterial role in the development of autoimmune disorders