genomic aberrations in an african american colorectal cancer cohort reveals a msi-specific profile and chromosome x amplification in male patients基因畸变的非裔美国人结直肠癌组揭示了一个msi-specific形象和男性患者的染色体x放大.pdfVIP

Genomic Aberrations in an African American Colorectal Cancer Cohort Reveals a MSI-Specific Profile and Chromosome X Amplification in Male Patients 1 1 2 3 1 Hassan Brim *, Edward Lee , Mones S. Abu-Asab , Mohamed Chaouchi , Hadi Razjouyan , 1 4 ¨ 5 1 Hassanzadeh Namin , Ajay Goel , Alejandro A. Schaffer , Hassan Ashktorab * 1 Department of Medicine and Cancer Center, College of Medicine, Department of Pathology, Howard University, Washington, D.C., United States of America, 2 National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, United States of America, 3 Department of Physiology and Biophysics, Georgetown University School of Medicine, Washington, D.C., United States of America, 4 Baylor Research Institute and Sammons Cancer Center, Baylor University Medical Center, Dallas, Texas, United States of America, 5 National Center for Biotechnology Information, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, United States of America Abstract Objective: DNA aberrations that cause colorectal cancer (CRC) occur in multiple steps that involve microsatellite instability (MSI) and chromosomal instability (CIN). Herein, we studied CRCs from AA patients for their CIN and MSI status. Experimental Design: Array CGH was performed on 30 AA colon tumors. The MSI status was established. The CGH data from AA were compared to published lists of 41 TSG and oncogenes in Caucasians and 68 cancer genes, proposed via systematic sequencing for somatic mutations in colon and breast tumors. The patient-by