gwa analysis for milk production traits in dairy sheep and genetic support for a qtn influencing milk protein percentage in the lalba genegwa乳制品绵羊和牛奶产量性状的遗传分析支持本考察团lalba基因影响牛奶蛋白百分比.pdfVIP

GWA Analysis for Milk Production Traits in Dairy Sheep and Genetic Support for a QTN Influencing Milk Protein Percentage in the LALBA Gene ´ ´ 1. ´ 1. 2 ´ 3 ´ 1 Elsa Garcıa-Gamez , Beatriz Gutierrez-Gil , Goutam Sahana , Juan-Pablo Sanchez , Yolanda Bayon , ´ 1* Juan-Jose Arranz ´ ´ ´ 1 Departmento Produccion Animal, Universidad de Leon, Leon, Spain, 2 Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark, 3 Mejora ´ Genetica Animal, IRTA, Lleida, Spain Abstract In this study, we used the Illumina OvineSNP50 BeadChip to conduct a genome-wide association (GWA) analysis for milk production traits in dairy sheep by analyzing a commercial population of Spanish Churra sheep. The studied population consisted of a total of 1,681 Churra ewes belonging to 16 half-sib families with available records for milk yield (MY), milk protein and fat yields (PY and FY) and milk protein and fat contents (PP and FP). The most significant association identified reached experiment-wise significance for PP and FP and was located on chromosome 3 (OAR3). These results confirm the population-level segregation of a previously reported QTL affecting PP and suggest that this QTL has a significant pleiotropic effect on FP. Further associations were detected at the chromosome-wise significance level on 14 other chromosomal regions. The marker on OAR3 showing the highest significant association was located at the third intron of