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foxp3~+ 调适性t 细胞.pdf

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22 6 Vol. 22, No. 6 2010 6 Chinese Bulletin of Life Sciences Jun., 2010 1004-0374(2010)06-0515-14 FOXP3+ T 200025 T T T T FOXP3 T T FOXP3+ T T F O X P 3 R392.12 A + FOXP3 regulatory T cells CHEN Zuo-jia, GAO Ya-yi, LI Zhi-yuan, LI Bin* (Key Laboratory of Molecular Virology Immunology, Unit of Molecular Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China) Abstract: Regulatory T cells (Tregs) play a fundamental role in maintaining immune homeostasis in vivo. Treg cells have been actively involved in controlling major human diseases including autoimmune diseases, infec- tious diseases, allergic diseases and the immune surveillance of tumors. The forkhead family transcription factor FOXP3 is a master regulator of natural Treg development and function. The underlying mechanism by which FOXP3 functions in Treg cells is dependent not only on FOXP3 transcription and expression, but also on FOXP3 posttranslational modification and transcriptional complex ensemble with other cofactors including protein posttranslational modification enzymes. Understanding the FOXP3 biochemistry and its dynamic en- semble with enzymatic cofactors will lead to novel therapeutic approaches for treating autoimmunity, infection, allergy, organ transplantation and cancer immunotherapy. Key Words: regulatory T cells; FOXP3; post translational modification + + + FOXP3 T (FOXP3 Tregs)T 1FOXP3 T CD4CD25 FOXP3 F O X P 3 + T r e g s T