西安交通大学医学院血液系统疾病课件 Leukemia.pptVIP

Leukemia What is leukemia Stem cell disease malignant cloning 　 leukemic stem/progenitor cells production differentiation/maturation stop　 infiltration of tissues/oranges　　 　　　　lymphoid (B/T) 　 myeloid (MM/E/Meg) immature mature immature mature 　 acute chronic acute chronic Classification of leukemia According to maturation and natural disease stage: Acute leukemia (AL)： 　 low grade differentiation with the most of blast / immature cells, disease develops very fast and prognosis is very bad, mean natural disease stage is about 3 months or so. Chronic leukemia (CL): high grade differentiation with the most near mature /mature cells, disease develops relatively slowly and prognosis is comparatively good, mean natural disease stage is several years . 　　 According to involved cell line: Acute leukemia: Acute lymphoblast leukemia(ALL):L1-L3 Acute myelocytic leukemia (AML): M1-M7 Or acute non-lymphocytic leukemia (ANLL) Chronic leukemia: Chronic myelocytic leukemia (CML) Chronic lymphocytic leukemia (CLL) Hairy leukemia (HL) Current status of leukemia in China Incidence of leukemia is 2-3/100,000 with the tendency of increasing yearly! Low than Europe and America, same as Asian countries Acute chronic（5.5:1） ANLL ALL（adult / children） CML CLL Causes and mechanisms Virus etiology: RNA virus (RT-virus)， HTLV-1, Radiation：x-ray, r-ray, isotope， Chemicals and drugs: anti-tumor drugs, antibiotics: chloramphenicol, chemicals: benzene, Hereditory factors：family leukemia, chromosome changes, tumor gene expression Develop from other blood diseases：MDS, PNH, ML, 　MM,MF, Acute leukemia Classification of acute leukemia (FAB) ALL subtypes: L1-L3 L1: small lymphoblast and immature lymphocytes with comparative good prognosis L2: small and large lymphoblast and immature lymphocytes with comparative bad prognosis L3: large lymphoblast and i