西安交通大学医学院血液系统疾病课件 LEUKOPENIA AND NEUTROPENIA.pptVIP

LEUKOPENIA AND NEUTROPENIA Definitions The normal WBC ranges form 4.0 to 10.0×109/L Leukopenia exists when WBC is less than 4.0×109/L. Neutropenia exists when neutrophil is less than 2.0×109/L. Agranulocytosis indicates severe neutropenia, i.e., neutrophil is less than 0.5×109/L. Referential values of BRT Table 1. Deferential values for blood routine test in different age and sex ___________________________________ male female newborn ___________________________________ RBC 4.0-5.5 3.5-5.0 6.0-7.0 HB 120-160 110-150 170-200 WBC 4-10 4-10 15-20 PLT 100-300 100-300 ___________________________________ Table 2 Referential values of differential count  ___________________________________ type percent value(%) absolute value ___________________________________ N st 1-5 0.04-0.5 N se 50-70 2-7 LYM 20-40 0.8-4 Mo 3-8 0.12-0.8 Eo 0.5-5 0.02-0.5 Ba 0-1 0-0.1 ___________________________________ Mechanisms Stem cell pool mitoson pool Store pool Marge pool Circulating pool Causes Acquired neutropenia Postinfectious Drug induced Benign familial neutropenia Chronic idiopathic neutropenia Autoimmune neutropenia Neutropenia associated with immunologic abnormalitie Neutropenia associated with metabolic diseases Neutropenia due to increased margination Nutritional deficiency Classification Deficiency of production Increase of destroy and consumption Abnormalies of distribution Clinic manifestations Infections: Mild: neutrophil is than 1.0×109/L Medeaum : 0.5-1.0×109/L Sev