胺碘酮协同卡托普利对老年高血压伴阵发性心房颤动的的疗效观察.docVIP

胺碘酮协同卡托普利对老年高血压伴阵发性心房颤动的的疗效观察 　　[摘要] 目的:观察卡托普利联合胺碘酮治疗老年高血压伴阵发性心房颤动(房颤)患者的疗效。方法:将70例老年高血压伴阵发性房颤患者随机分为胺碘酮组和联合用药组(卡托普利联合胺碘酮),治疗12个月,计算两组治疗后第3、6、9、12个月的窦性心律维持率和治疗前及治疗后第6、12个月的左心房内径。结果:研究期结束后各组内治疗前后血压变化比较具有显著性,但两组间治疗后血压无显著性差异。治疗后9、12个月,联合用药组的窦性心律维持率显著高于胺碘酮组。两组间左心房内径在治疗后12个月时胺碘酮组显著高于联合用药组。结论:卡托普利联合胺碘酮治疗老年高血压伴阵发性房颤,可抑制左房扩大,并有效预防房颤复发。 　　[关键词] 卡托普利;胺碘酮;老年高血压;心房颤动 　　[中图分类号] R541.3[文献标识码]A [文章编号]1673-7210(2009)07(c)-060-02 　　 　　The clinical research of the treatment of Captopril and Amiodarone to elderly hypertensive patients with paroxysmal atrial fibrillation 　　XIE Jilian, LIN Xiaoqing, LI Shining 　　(The Medical Services Department of Dongguan Hospital of the Third Bureau, Dongguan 523710, China) 　　[Abstract] Objective: To evaluate the treatment of Captopril and Amiodarone to cure the elder hypertension and paroxysmal atrial fibrillation. Methods: 70 cases of elderly hypertensive patients with paroxysmal atrial fibrillation were randomly divided into Amiodarone group and combination group (Captopril combined Amiodarone), they were treated of 12 months, the rhythm control of the two groups after treatment 3, 6, 9,12 months and the left atrial diameter after treatment 6, 12 months were calculated. Results: There were significant changes of the blood pressure after treatment in each group, but no significant difference between two groups. The rate of rhythm control of the combination group was significant higher than that of the Amiodarone group after 9 and 12 months treatment. The change of the left atrial diameter was significant between the two groups after 12 months treatment. Conclusion: Captopril combined with Amiodarone can decrease the blood pressure, inhibit left atrial enlargement and effective in preventing recurrence of atrial fibrillation in elderly hypertensive paroxysmal atrial fibrillation. 　　[Key words] Captopril; Amiodarone; Elderly hypertensive; Paroxysmal atrial fibrillation 　　 　　老年高血压病的发病机制与中、青年高血压病有所不同, 其中复杂因素是年龄和长期高血压对靶器官的影响,可导致多种心律失常,其中心房颤动(简