孕期高危型HPV感染与子痫前期相关性分析.docVIP

孕期高危型HPV感染与子痫前期相关性分析 　　[摘要] 目的 研究并分析孕期高危型HPV感染?c子痫前期的相关性。 方法 选取2014年3月～2016年2月来我院就诊的子痫前期孕妇102例设为观察组，另取同期正常妊娠孕妇102例设为对照组。比较两组高危型HPV感染发生情况以及血清IL-2、IL-10水平。同时，比较观察组不同高危型HPV感染孕妇的血清IL-2、IL-10水平，并进行相关性分析。 结果 观察组孕妇高危型HPV感染阳性率为47.06%（48/102），显著高于对照组的9.80%（10/102），差异有统计学意义（P0.05）。观察组血清IL-2水平显著高于对照组，而IL-10水平显著低于对照组，差异均有统计学意义（P0.05）。高危型HPV感染阳性组孕妇血清IL-2水平显著高于阴性组，而IL-10水平显著低于阴性组，差异均有统计学意义（P0.05）。经Spearman相关性分析可知，孕期高危型HPV感染与子痫前期存在显著正相关关系（r=0.572，P=0.014）。 结论 孕期高危型HPV感染与子痫前期存在显著正相关关系，临床工作中可通过预防高危型HPV感染，以降低子痫前期的发生率。 　　[关键词] 高危型HPV；子痫前期；孕妇；白细胞介素-2；白细胞介素-10 　　[中图分类号] R714 [文献标识码] B [文章编号] 1673-9701（2017）04-0062-03 　　Analysis of the correlation between high-risk HPV infection and preeclampsia during pregnancy 　　WEN Haiyan1 LI Xiaohong2 　　1.Department of Obstetrics，Hangzhou Women’s Hospital in Zhejing Province，Hangzhou 310000，China；2.Department of Obstetrics， Rui’an Women and Children’s Hospital in Zhejiang Province，Rui’an 325200，China 　　[Abstract] Objective To study and analyze the correlation between high-risk HPV infection and preeclampsia during pregnancy. Methods A total of 102 pregnant women with preeclampsia who were diagnosed in our hospital from March 2014 to February 2016 were assigned to the observation group. Another 102 cases of normal pregnant women in the same period were assigned to the control group. The incidence of high-risk HPV infection and serum IL-2 and IL-10 levels were compared between the two groups. Meanwhile，the levels of serum IL-2 and IL-10 in the pregnant women with different high-risk HPV infections were compared in the observation group，and correlation analysis was performed. Results The positive rate of high-risk HPV infection in the observation group was 47.06%（48/102），which was significantly higher than that in the control group [9.80%（10/102）]. The difference was statistically significant（P 　　[Key words] High-risk HPV；Preeclampsia；Pregnant women；IL-2；IL-10 　　子痫前期属于妊娠期孕妇所特有的疾病，亦是导致孕产妇死亡的重要原因之一，且会增加新生儿发病率以及死亡率，严重影响了孕产妇及胎儿的生命健康安全[1]。其中高危型人乳头瘤