缺血性脑卒中与血浆纤维蛋白原相关性研究.docVIP

缺血性脑卒中与血浆纤维蛋白原相关性研究 　　【摘要】 目的 探讨缺血性脑卒中与血浆纤维蛋白原之间关系。 方法 检测128例缺血性脑卒中患者（急性期和恢复期）及30名正常对照者血浆中纤维蛋白原浓度，并与神经功能缺损程度进行相关分析。结果 ①缺血性脑卒中患者急性期与恢复期纤维蛋白原浓度显著高于对照组;②纤维蛋白原浓度与神经功能缺损程度评分显著正相关（P 　　【关键词】 缺血性脑卒中 ； 纤维蛋白原 　　 　　A Study on the Relation of Plasma Fibrinogen in Patients with Ischemic Cerebrovascular Disorder WANG Hui , LI Hong - xue,LIU Jing - yu. The second Department of Neurology, Hei Long - jiang Province Land Reclamation Headquarters General Hosipital, Harbin 150088,China 　　【Abstract】 Objective To investigate the changes of plasma fibrinogen in patients with ischemic cerbrorascular disorder. Methods Totally, 128 cases of ischemic cerbrorascular disorder (both acute and decubation) and 30 normal controls were tested for their content of plasma fibrinogen and their correlation with neurological functional deficit scale. Results ①The content of plasma fibrinogen in acute stage in ischemic cerbrorascular disorder was markedly higher than that in controls (P＜0．01).The content of plasma fibrinogen in convalescence is still higher than that of the controls (P＜0．01) . ②The content of plasma fibrinogen was positively related with neurological functional deficit scale. (P＜0．01). Conclusion The content of plasma fibrinogen was markedly raised in the acute stage in ischemic cerbrorascular disorder, which shows that it might participate in the pathologic process of ischemic cerebral injury and reflects the degree of disease indirectly. The content of plasma fibrinogen in decubation group higher than the controls it indicates that positive treatment is need: for patients. 　　【Key words】 Ischemic Cerbrorascular Disorder;Fibrinogen. 　　 　　近年来，纤维蛋白原（Fg）与缺血性脑卒中的关系备受临床重视。已证实Fg参与血栓形成的主要病理过程，血浆Fg水平升高已成为缺血性脑卒中的危险因素，本研究测定缺血性脑卒中患者Fg含量，以进一步探讨其变化规律及 　　临床意义。 　　 　　1 资料与方法 　　 　　1．1 一般资料 　　1．1．1 缺血性脑卒中组 选择2004年10月至2006年6月在我院神经内科住院的首???缺血性脑卒中患者128例，男75例，女53例。年龄46～81岁，平均（65．3±11．0）岁。全部病例均符合1995年全国第四届脑血管疾病会议修订的诊断标准[１]。所有患者均于1～72 h发病且经颅脑CT排除脑出血、组织损伤（如心脏梗死、外科手术等）。 　　1．1．2 正常对照组 选择于我院体检中心体检的与缺血