可切除直肠癌术前放化疗研究进展.pdfVIP

癌《症》ChineseJournalofCancer，2008，27(12)：1341—1344 l341 · 综 可切除直肠癌术前放化疗研究进展 ‘ 陈远航 ， 李志平 AdvanceinPreoperativeRadiochemotherapyforResectableRectalCancer CHENYuan—Hang．LlZhi—Ping [ABSTRACT] Theaim ofpreoperativeradiotherapyforrectalcanceristo improvethelocalcontrolrate，increasethepossibilityforsphincterpreservation， and improvethe survivaIandthequalityoflife．Randomized clinicaltrialshave shownthatcombining radicalsurgerywithpreoperativeradiochemotherapy is more effective in improving the localcontrolrate ascompared with radical surgery orpreoperativeradiotherapyalone．With introductionofmoreeffective novelchemotherapeuticagentsand schemesoftheircombination，multimodal treatmentwithpreoperative radiochemotherapywillbe applied individuallyto treatselected patients， whichisexpectedtofurtherenhancethetherapeutic effectofrectalcancer．Thisarticlereviewedthecurrentstatusanddevelopment ofpreoperativeradiochemotherapyforrectalcancer KEYWORDS：Rectalneoplasm；Preoperative；Radiotherapy；Chemotherapy； Combined therapy 摘【 要】 术前放疗在直肠癌综合治疗 中的目标是提高局部控制率，增加保肛的 几率 ，提高生存率及生活质量。随机临床研究已证实术前放疗联合化疗的综合治 疗 ，较单纯手术或术前联合单纯放疗可显著提高肿瘤的局部控制率。更多有效的 药物及新配伍方案的引入 ，对直肠癌患者采取个体化的术前放化疗 ，将使直肠癌 的治疗效果得到进一步提高。本文综述了直肠癌术前放化疗的现状和进展。