copd急性加重期伴呼吸衰竭患者氧化应激水平在其预后早期评估中的临床价值.docVIP

COPD急性加重期伴呼吸衰竭患者氧化应激水平在其预后早期评估中的临床价值 　　【摘要】 目的：探?慢性阻塞性肺疾病（COPD）急性加重期伴呼吸衰竭患者氧化应激水平在其预后早期评估中的临床价值。方法：选取2012年1月-2014年8月本院收治的COPD急性加重期伴呼吸衰竭患者85例为研究组，另选取30例COPD稳定期患者为对照组。检测两组治疗前、治疗3 d和1周的血清8-isoprostane、超氧化物歧化酶（SOD）、丙二醛（MDA）和总抗氧化能力（T-AOC）等氧化应激指标，采用Kaplan-Meier生存曲线分析两组随访1年的预后情况，比较不同预后情况COPD急性加重期伴呼吸衰竭患者治疗前后的氧化应激指标水平并采用Spearman无条件相关分析法和Logistic多元回归分析法分析其氧化应激指标水平与预后的关系。结果：与对照组比较，研究组治疗前后的血清SOD、T-AOC水平均降低（P 　　【关键词】 COPD； 急性加重期； 呼吸衰竭； 氧化应激水平； 预后； 早期评估 　　Clinical Value of Oxidative Stress Level in Early Assessing the Prognosis of COPD Patients with Respiratory Failure in Acute Exacerbation Period/CHEN Yong-xiang.//Medical Innovation of China，2017，14（06）：001-005 　　【Abstract】 Objective：To investigate the clinical value of oxidation stress level in early assessing the prognosis of chronic obstructive pulmonary disease（COPD） patients with respiratory failure in acute exacerbation period.Method：85 COPD patients with respiratory failure in acute exacerbation period in our hospital from January 2012 to August 2014 were selected as the research group，and 30 patients with COPD in stabilization period were selected as the control group.Before treatment and after treated with 3 d and 1 week serum 8-isoprostane，superoxide dismutase（SOD），malondialdehyde（MDA） and total antioxidant capacity（T-AOC） and other oxidative stress indicators level of the research group and control group were tested.Kaplan Meier survival curve was applied in analysis of the prognosis of two groups in 1 year followed up and the oxidative stress indexes level of patients with different prognosis in COPD patients with respiratory failure in acute exacerbation period before and after treatment were compared.Spearman unconditionally correlation analysis and Logistic multivariate regression analysis method were applied to analyze the relationship between serum oxidative stress index level with the prognosis.Result：Compared with the control group，serum SOD and T-AOC level of the research group before and after treatment