胰岛素样生长因子-1在儿童性早熟中的诊断价值.docVIP

精品论文 参考文献 胰岛素样生长因子-1在儿童性早熟中的诊断价值 1天津医科大学研究生院 天津300070，天津医科大学宝坻临床学院 天津 301800；2天津医科大学总医院儿科 天津 300020 【摘要】：目的：分析胰岛素样生长因子-1在儿童性早熟中的诊断价值。方法：选取2015年6月-2016年3月50例特发性中枢性性早熟女孩、50例单纯性乳房早发育女孩，再选取同时段50例正常发育女孩作为对照组。观察三组之间的IGF-1差异。结果：特发性中枢性性早熟组、单纯性乳房早发育组及对照组的IGF-1水平为（362.45plusmn;109.45）ng/mL、（231.58plusmn;81.63）ng/mL和（221.58plusmn;86.95）ng/mL，特发性中枢性性早熟组的IGF-1水平显著高于单纯性乳房早发育组及对照组，比较差异有统计学意义（P＜0.05），但单纯性乳房早发育组与对照组之间的差异无统计学意义。结论：IGF-1在特发性中枢性性早熟中具有较高的敏感度，并且在特发性中枢性性早熟与单纯性乳房早发育中具有较好的鉴别作用。 【关键词】：胰岛素样生长因子-1；特发性中枢性性早熟；单纯性乳房早发育 【中图分类号】R186【文献标识码】A【文章编号】1001-5213(2016)09-0070-02 [Abstract] Objective: to analyze the diagnostic value of insulin like growth factor -1 in children with precocious puberty. Methods: 50 girls with idiopathic central precocious puberty, 50 cases of simple breast development girls were selected from January -2016, and 50 normal girls were selected as control group. IGF-1 differences between the three groups were observed. Results: idiopathic central precocious puberty group, simple breast early development group and control group IGF-1 levels for (362.45 + 109.45) ng / ml, (23.158 + of 81.63) ng / ml and 22.158 + 86.95 ng / ml, special hair central precocious puberty group IGF-1 level was significantly higher than that of pure breast early development group and the control group, the difference has statistical significance (P lt; 0.05), but pure breast early development group and control group differences had no statistical significance. Conclusion: IGF-1 has high sensitivity in the idiopathic central precocious puberty, and it has a good effect in the early development of the central precocious puberty and early breast development. [Key words]: insulin like growth factor -1; idiopathic central precocious puberty; simple breast development 性早熟对于儿童的健康成长具有重要影响，可导致儿童人格受到影响，引发一系列社会问题。因此，早期诊治性早熟具有重要意义。文章主要针对鹊核匮ひ蜃釉诙栽缡熘械恼锒霞壑到蟹治觯ǖ廊缦隆 1.资料与方法 1.1临床资料 选取2015年6月-2016年3月50例特发性中枢性性早熟女孩、50例单纯性乳房早发育女孩，再选取同时段50例正常发育女孩作为对照组。特发性中枢性性早熟及