心力衰竭患者血NT-proBNP与心功能之间的相关性.docVIP

精品论文 参考文献 心力衰竭患者血NT-proBNP与心功能之间的相关性 丛蓓 姜涵 李明生 张小冲 　　（大连港医院 116001） 　　【摘要】目的 探讨心力衰竭（HF）患者血浆N-末端脑钠肽（NT-proBNP）与心功能严重程度的相关性，评价其对心力衰竭患者的临床意义。方法：心力衰竭患者140例，按纽约心脏病协会（NYHA）心功能分级，其中NYHAⅡ级52例、Ⅲ级56例、Ⅳ级32例，同时选取68例心功能正常人作为对照组，分别测定血浆NT-proBNP值及左室射血分数（LVEF）。结果 心力衰竭组NT-proBNP数值明显高于对照组，且其数值随心功能分级的升高而增高，与LVEF呈负相关（P＜0.05）。结论 心力衰竭患者血NT-proBNP水平与心力衰竭严重程度存在相关性，可客观反映心力衰竭患者的心功能状态。 　　【关键词】N-末端脑钠肽 心力衰竭 左室射血分数 　　【中图分类号】R541.6 【文献标识码】A 【文章编号】2095-1752（2013）34-0128-02 　　Relationship between plasma N-terminal pro-brain natriuretic peptide levels in patients with heart failure 　　Cong Pei Jiang Han ,Li Ming-sheng ,Zhang Xiao-chong Department of Cardiology，Da Lian Harob Hospital, Dalian，China 　　【Abstract】Objective To investigate the relationship between N-terminal pro-brain natriuretic peptide (NT-proBNP) levels in patients with the deterioration of the heart failure severity. Methods 140 patiants with heat failure were selected among them（ 52 subjets with NYHAⅡ,56subjets with NYHA Ⅲ,32 subjets with NYHA Ⅳ）, and 68 subjets were enrolled in contorl group. The plasma level of NT-proBNP were detected by electrochemiluminescence immunoassay methed,and the structure and fuction of left ventricle were examined by echocardiography. Results The plasma level of NT-proBNP increased significantly in patients with heart failure compard with control groups,and the dregreed of NYHA.The levels of plasma NT-proBNP were negatively correlated with LVEF.Conclusions The plasma level of NT-proBNP has the realationship with the deterioration of the heart failure severity,and it can be used to evaluate the function in the elderly patients with heart failure. 　　【Key words】N-terminal pro-brain natriuretic peptide (NT-proBNP) Heart failure(HF) LVEF 　　慢性充血性心力衰竭（congestive heart failure CHF）是一种以心室功能不全、神经内分泌激活和外周血流分布异常为特征的复杂临床综合征，目前临床上患病率很高，随着年龄的增长，心力衰竭的发生率显著上升，其死亡率也明显上升，故心衰的预防和治疗已经成为我国主要和逐渐增长的公共卫生问题，故对心力衰竭病人，应早发现、早诊断、早治疗。目前BNP和NT-proBNP测定广泛应用于慢性心力衰竭的