健脾化痰祛瘀方防治腹透患者腹膜纤维化60例临床研究.PDFVIP

-70- Clinical Journal of Chinese Medicine 2015 Vol.(7) No.30 健脾化痰祛瘀方防治腹透患者 腹膜纤维化 60 例临床研究 Clinical study of prevention and treatment of 60 cases with peritoneal dialysis-related peritoneal fibrosis by Jianpi Huatan Quyu decoction * 孟立锋 谢永祥 陶志虎 杨端云 （广西中药大学第一附属医院，广西 南宁，530023） 中图分类号：R255.9 文献标识码 ：A 文章编号 ：1674-7860（2015）30-0070-04 证型 ：IDGB 【摘 要】目的：观察健脾化痰祛瘀方防治腹透相关性腹膜纤维化的临床疗效。方法：按纳入标准选取 2013 年 1 月—2015 年 1 月腹膜透析患者 60 例，随机分为治疗组 30 例（基础治疗加健脾化痰祛瘀方），对照组（基础治疗）30 例。随访 6 个月，观 察治疗前后，腹透患者痰瘀互结临床证候及腹透液中 TGF-β1、VEGF 、α-SMA 及 E-cadherin 因子水平变化。结果：治疗后，两组 组间比较，治疗组临床证候积分及腹透液中 TGF-β1、VEGF 及 α-SMA 因子下降水平与对照组比较有统计学差异（P ＜0.05 ）。腹透 液中 E-cadherin 蛋白的表达上升水平与对照组比较有统计学差异（P ＜0.05 ）。结论：健脾化痰祛瘀方有较好的防治腹膜纤维化、 保护腹膜功能的作用。 【关键词】腹膜透析；腹膜纤维化；健脾化痰祛瘀方；临床疗效 【Abstract 】Objective ：To observe the clinical therapeutic effect of Jianpi Huatan Quyu Decoction in the prevention and treatment of peritoneal dialysis-related peritoneal fibrosis. Methods ：Sixty qualified patients were randomized into the treatment group and the control group with digital sorting method. Each group contains thirty patients. Both groups received routine basic treatment and additionally the treatment group received oral use of Jianpi huatan quyu Decoction ．A 6 -month follow- was carried out to observe the change in patients on peritoneal dialysis of clinical symptoms and the level of TGF-β1,VEGF α-SMA，E －cadherin expression in peritoneal fluid and the impact of Jianpi huatan quyu Decoction. Results ：After treatment, comparison between the two groups, the treatment group clinical symptoms and levels of peritoneal dialysis effluent decrement (TGF-β1,VEGF,α-SMA) were si