2015年某院门诊处方超说明书用药情况调查分析.docVIP

精品论文 参考文献 2015年某院门诊处方超说明书用药情况调查分析 凉山州第二人民医院 四川 西昌 615000 [基金项目] 2015年凉山州学术和技术带头人培养资金资助项目 [作者简介] 陈兴钰，女，（1980.11-）本科，主管药师，，研究方向：临床药学。 [通讯作者]莫超，男，（1982.10-）本科，主管药师，凉山州第二人民医院，研究方向：临床药学 [摘要] 目的：调查我院门诊处方超说明书用药情况，为开展药学服务，促进安全合理用药提供依据。 方法：随机抽取我院2015年全年门诊处方，依据药品说明书内容判断是否超说明书用药，并对超说明书用药发生率、类型及药品种类等进行统计分析。 结果：我院门诊处方超说明书用药按处方和用药记录统计发生率分别为9.54%和5.15%；超适应症、超给药频次及超给药途径占超说明书用药类型的89.26%；发生率排前3位的是消化内科、皮肤科及儿科；易发生超说明书用药的药品为抗脑血管药、皮肤科用药和抑酸药物；女性患者和青少年（12～＜18岁）超说明书用药风险更高（Plt;0.05）；正高级职称医师超说明书用药发生率和风险都明显高于其它职称医师（Plt;0.05）。 结论：我院门诊处方用药存在超说明书用药的情况，应加强对超说明书用药的管理。 关键字：超说明用药；门诊处方；调查分析；风险因素 【中图分类号】R646【文献标识码】A【文章编号】1001-5213(2016)09-0273-02 The Survey and Analysis of Off-label Drug Use of Outpatient Prescriptions in One Hospital in 2015 ABSTRACT OBJECTIVE: To investigate off-label drug use in outpatient prescriptions in one hospital,so as to provide evidence for launching pharmaceutical care and improving the rationality drug use. METHODS：Outpatient prescriptions in 2015 were randomly selected. The medical orders were judged for off-label drug use according to the drug instructions,and the off -label use was analyzed according to the rate of off -label use , the types of off -label use and categories of medicine. RESULT: The incidence rates of off-label drug use of prescriptions and records were 9.54% and 5.15% respectively. Accounting for over 89.26% of types of off -label use is indications, frequency and administration route. The top 3 departments with highest incidence rates of off-label drug use in outpatient were Deparmtent of Gastroenterology, Deparmtent of Dermatology and Deparmtent of Pediatrics. The top 3 categories of medicines in off -label use were Anti-cerebral vascular drugs,Dermatology drugs, Acid-suppressing drugs.Female patients and adolescent patients (12-＜18 years old ) might have higher risk factors of off -label drug use (P lt; 0.05)。The incidence rate and risk of off-label drug use of the prescriptions prescribed by doctors with senior professional title were significan