26例癫痫性脑病伴爆发-抑制的临床与脑电图分析.docVIP

精品论文 参考文献 26例癫痫性脑病伴爆发-抑制的临床与脑电图分析 蒋铁甲 　　(浙江大学医学院附属儿童医院 浙江 杭州 310003) 　　【摘要】 目的：通过总结26例癫痫性脑病伴爆发-抑制(EIEE)的临床与脑电图（EEG）特点，病程及预后特征,提高对该病临床脑电特征及预后的认识。方法：回顾性分析26例EIEE的临床与脑电图资料。结果：26例患儿病程中均有强直痉挛发作史，10例患儿有部分性发作，1例患儿有非对称惊厥发作。首诊发作间期EEG检查均为暴发抑制型（S—B）EEG。11例母孕史及出生史异常，7例头颅影像学检查异常。21例患儿接受抗癫痫药物或抗癫痫药物加激素联合治疗，仅1例接受抗癫痫药物联合治疗患儿发作控制。其余5例患儿家长放弃治疗，26例患儿均有严重的精神发育落后。结论：新生儿和早期婴儿强直痉挛性发作，脑电图检查为爆发抑制波形是大田原综合症两大主要特征，部分患儿可合并部分性发作，本病可由多种病因引起，药物治疗效果差，预后不良。 　　【关键词】癫痫性脑病伴爆发-抑制；爆发抑制波；强直痉挛性发作 　　【中图分类号】R74 【文献标识码】A 【文章编号】2095-1752（2015）22-0028-03 　　26 cases of epileptic encephalopathy associated with outbreaks - inhibiting the clinical and eeg analysis 　　Jiang Tiejia. Zhejiang University School of Medicine Affiliated Childrens Hospital, Zhejiang Province, Hangzhou 310003, China 　　【Abstract】 Objective Through summarizing of 26 cases of epileptic encephalopathy with explosion suppression (EIEE) in clinical and electroencephalogram (EEG) features, progression and prognosis of characteristics, improve the understanding of clinical EEG characteristics and prognosis of the disease. Methods 26 cases were retrospectively analyzed the clinical and eeg data of EIEE. Results 26 cases in the course of the disease are tetanic convulsion attack, 10 cases with partial onset seizures, 1 cases with asymmetric seizure. First onset period between EEG examination for outbreak inhibited type EEG (S - B). 11 cases of abnormal maternal history of pregnancy and birth history, 7 cases of cranial imaging abnormalities. 21 cases received antiepileptic drug or combination treatment with antiepileptic drugs and hormones, only 1 case received antiepileptic drug combination therapy with seizure control. The remaining 5 cases of parents to give up treatment, 26 cases were serious mental development lag behind. Conclusions Early newborn and infant tetanic convulsive seizures, eeg examination for the outbreak of inhibition of waveform are two big infrastructure syndrome characteristics, some