有哪些信誉好的足球投注网站csf metabolic and proteomic profiles in patients prodromal for psychosis患者的csf代谢和蛋白质组配置文件有前驱症状的精神病.pdfVIP
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csf metabolic and proteomic profiles in patients prodromal for psychosis患者的csf代谢和蛋白质组配置文件有前驱症状的精神病
CSF Metabolic and Proteomic Profiles in Patients Prodromal for Psychosis 1. 2. 3. 2 2 2 2 Jeffrey T.-J. Huang , F. Markus Leweke , Tsz M. Tsang , Dagmar Koethe , Laura Kranaster , Christoph W. Gerth , Sonja Gross , Daniela 2 2 2 ¨ 2 3 1 Schreiber , Stephan Ruhrmann , Frauke Schultze-Lutter , Joachim Klosterkotter , Elaine Holmes , Sabine Bahn * 1 Institute of Biotechnology, University of Cambridge, Cambridge, United Kingdom, 2 Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany, 3 Department of Biomolecular Medicine, Division of SORA, Faculty of Medicine, Imperial College, London, United Kingdom Background. The initial prodromal state of psychosis (IPS) is defined as an early disease stage prior to the onset of overt psychosis characterized by sub-threshold or more unspecific psychiatric symptoms. Little is known regarding the biochemical changes during this period. Methodology/Principal Findings. We investigated the metabolic/proteomic profiles of ¨ cerebrospinal fluid (CSF) of first-onset drug naıve paranoid schizophrenia patients (n = 54) and individuals presenting with initial prodromal symptoms (n = 24), alongside healthy volunteers (n = 70) using proton nuclear magnetic resonance (1H-NMR) spectroscopy and surface enhanced laser desorption ionization (SELDI) mass spectrometry, respectively. Partial least square discriminant analysis (PLS-DA) showed that 36%/29% of IPS patients displayed proteomic/metabolic
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