csf-biomarkers in olympic boxing diagnosis and effects of repetitive head trauma奥运拳击csf-biomarkers诊断和重复的头部创伤的影响.pdfVIP

CSF-Biomarkers in Olympic Boxing: Diagnosis and Effects of Repetitive Head Trauma Sanna Neselius1,2*, Helena Brisby 1,2, Annette Theodorsson3,4, Kaj Blennow5,6, Henrik Zetterberg5,6, Jan Marcusson4,7 1 Department. of Orthopaedics, Sahlgrenska University Hospital, Gothenburg, Sweden, 2 Institution For Clinical Sciences, The Sahlgrenska Academy at University of ¨ ¨ ¨ Gothenburg, Sweden, 3 Neurosurgery Section, University Hospital in Linkoping, Linkoping, Sweden, 4 Institution of Clinical and Experimental Medicine, Linkoping ¨ University, Linkoping, Sweden, 5 Clinical Neurochemistry Laboratory, Department of Psychiatry and Neurochemistry, Sahlgrenska University Hospital, Gothenburg, Sweden, 6 Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, 7 Geriatric Section, University Hospital ¨ ¨ in Linkoping, Linkoping, Sweden Abstract Background: Sports-related head trauma is common but still there is no established laboratory test used in the diagnostics of minimal or mild traumatic brain injuries. Further the effects of recurrent head trauma on brain injury markers are unknown. The purpose of this study was to investigate the relationship between Olympic (amateur) boxing and cerebrospinal fluid (CSF) brain injury biomarkers. Methods: The study was designed as a prospective cohort study. Thirty Olympic boxers with a minimum of 45 bouts and 25 non-boxing matched controls were included in the study. CSF samples were collected by lumbar puncture 1–6 days after a bout and after a rest period for at least 14 days. The controls were tes