contrast dependence of smooth pursuit eye movements following a saccade to superimposed targets扫视后对比依赖光滑追求眼球运动的目标.pdfVIP

Contrast Dependence of Smooth Pursuit Eye Movements following a Saccade to Superimposed Targets 1 2 Mazyar Fallah *, John H. Reynolds 1 School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada, 2 Systems Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, California, United States of America Abstract Dorsal stream areas provide motion information used by the oculomotor system to generate pursuit eye movements. Neurons in these areas saturate at low levels of luminance contrast. We therefore hypothesized that during the early phase of pursuit, eye velocity would exhibit an oculomotor gain function that saturates at low luminance contrast. To test this, we recorded eye movements in two macaques trained to saccade to an aperture in which a pattern of dots moved left or right. Shortly after the end of the saccade, the eyes followed the direction of motion with an oculomotor gain that increased with contrast before saturating. The addition of a second pattern of dots, moving in the opposite direction and superimposed on the first, resulted in a rightward shift of the contrast-dependent oculomotor gain function. The magnitude of this shift increased with the contrast of the second pattern of dots. Motion was nulled when the two patterns were equal in contrast. Next, we varied contrast over time. Contrast differences that disappeared before saccade onset biased post-saccadic eye movements at short latency. Changes in contrast occurring during or after saccade termination did not influence eye movements for approximately 150 ms. Earlier studies found that eye movements can be explained by a vector average computation when both targets are equal in contrast. We suggest that this averaging computation may reflect a special