有哪些信誉好的足球投注网站cten is targeted by kras signalling to regulate cell motility in the colon and pancreascten是喀斯特的目标信号调节细胞运动性结肠癌和胰腺癌.pdfVIP
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cten is targeted by kras signalling to regulate cell motility in the colon and pancreascten是喀斯特的目标信号调节细胞运动性结肠癌和胰腺癌
Cten Is Targeted by Kras Signalling to Regulate Cell Motility in the Colon and Pancreas 1 1 1 1 1,2 Saleh Al-Ghamdi , Abdulkader Albasri , Julien Cachat , Salih Ibrahem , Belal A. Muhammad , Darryl 1 2 1 1,3 Jackson , Abdolrahman S. Nateri , Karin B. Kindle , Mohammad Ilyas * 1 Division of Pathology, Nottingham University, Nottingham, United Kingdom, 2 Division of Pre-Clinical Oncology, Nottingham University, Nottingham, United Kingdom, 3 Nottingham Digestive Diseases Centre, NIHR Biomedical Research Unit, Queen’s Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom Abstract CTEN/TNS4 is an oncogene in colorectal cancer (CRC) which enhances cell motility although the mechanism of Cten regulation is unknown. We found an association between high Cten expression and KRAS/BRAF mutation in a series of CRC cell lines (p = 0.03) and hypothesised that Kras may regulate Cten. To test this, Kras was knocked-down (using small interfering (si)RNA) in CRC cell lines SW620 and DLD1 (high Cten expressors and mutant for KRAS). In each cell line, Kras knockdown was mirrored by down-regulation of Cten Since Kras signals through Braf, we tested the effect of Kras knockdown in CRC cell line Colo205 (which shows high Cten expression and is mutant for BRAF but wild type for KRAS). Cten levels were unaffected by Kras knockdown whilst Braf knockdown resulted in reduced Cten expression suggesting that Kras signals via Braf to regulate Cten. Quantification of
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