有哪些信誉好的足球投注网站critical role of klf5 in regulating gene expression during post-eyelid opening maturation of mouse corneasklf5的至关重要的作用在调节基因表达在post-eyelid鼠标眼角膜的开始成熟.pdfVIP
- 1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
critical role of klf5 in regulating gene expression during post-eyelid opening maturation of mouse corneasklf5的至关重要的作用在调节基因表达在post-eyelid鼠标眼角膜的开始成熟
Critical Role of Klf5 in Regulating Gene Expression during Post-Eyelid Opening Maturation of Mouse Corneas 1.¤ 1. 1. 1 Doreswamy Kenchegowda , Stephen A. K. Harvey , Sudha Swamynathan , Kira L. Lathrop , Shivalingappa K. Swamynathan1,2,3* 1 Department of Ophthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, 2 Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, 3 McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America Abstract Background: Klf5 plays an important role in maturation and maintenance of the mouse ocular surface. Here, we quantify WT and Klf5-conditional null (Klf5CN) corneal gene expression, identify Klf5-target genes and compare them with the previously identified Klf4-target genes to understand the molecular basis for non-redundant functions of Klf4 and Klf5 in the cornea. Methodology/Principal Findings: Postnatal day-11 (PN11) and PN56 WT and Klf5CN corneal transcriptomes were quantified by microarrays to compare gene expression in maturing WT corneas, identify Klf5-target genes, and compare corneal Klf4- and Klf5-target genes. Whole-mount corneal immunofluorescent staining was employed to examine CD45+ cell influx and neovascularization. Effect of Klf5 on expression of desmosomal components was studied by immunofluorescent staining and transient co-transfection assays. Expression of 714 and 753 genes was increased, and 299 and 210 genes decreased in PN11 and PN56 Klf5CN corneas, respectively, with 366 concordant increases and 72 concordant decreases. PN56 Klf5CN corneas shared 241
您可能关注的文档
- conotoxins that confer therapeutic possibilities个基因治疗的可能性.pdf
- conotoxins therapeutic potential and application个与治疗和应用潜力.pdf
- consequences of cold-ischemia time on primary nonfunction and patient and graft survival in liver transplantation a meta-analysis冷缺血时间在原发性无功能的后果,病人和移植肝的生存在肝移植一个荟萃分析.pdf
- conjunctiva-associated lymphoid tissue (calt) reactions to antiglaucoma prostaglandins with or without bak-preservative in rabbit acute toxicity studyconjunctiva-associated淋巴组织(calt)反应antiglaucoma前列腺素有或没有bak-preservative在兔急性毒性研究.pdf
- consequences of gestational malaria on birth weight finding the best timeframe for intermittent preventive treatment administration妊娠期疟疾的后果在出生体重发现间歇性预防治疗的最佳时间管理.pdf
- connexin mediated cataract prevention in mice联接蛋白介导的白内障预防老鼠.pdf
- consequences of more intensive forestry for the sustainable management of forest soils and waters的后果更密集的森林可持续管理的森林土壤和水域.pdf
- consequences of non-intervention for infectious disease in african great apes不干涉的后果传染病在非洲类人猿.pdf
- consensus micro rnas governing the switch of dormant tumors to the fast-growing angiogenic phenotype共识微rna调节开关快速增长的休眠肿瘤血管生成表现型.pdf
- conservation and evolution of cis-regulatory systems in ascomycete fungi保护和子囊菌真菌基因的进化系统.pdf
- cross tissue trait-pathway network reveals the importance of oxidative stress and inflammation pathways in obesity-induced diabetes in mouse跨组织trait-pathway网络揭示氧化应激和炎症通路的重要性obesity-induced糖尿病老鼠.pdf
- critical role of the virus-encoded microrna-155 ortholog in the induction of marek's disease lymphomas关键作用的微rna病毒编码的感应- 155直接同源马立克氏病淋巴瘤.pdf
- critical role of perforin-dependent cd8+ t cell immunity for rapid protective vaccination in a murine model for human smallpox关键作用perforin-dependent cd8 + t细胞免疫的快速保护人类天花疫苗接种小鼠模型.pdf
- critical role of p53 upregulated modulator of apoptosis in benzyl isothiocyanate-induced apoptotic cell death关键作用的p53调节细胞凋亡的调制器苄isothiocyanate-induced凋亡细胞死亡.pdf
- crossing paths in human renal cell carcinoma (hrcc)穿越路径在人类肾细胞癌(hrcc).pdf
- cross-lineage influenza b and heterologous influenza a antibody responses in vaccinated mice immunologic interactions and byamagata dominancecross-lineage乙型流感和异种的流感接种小鼠的抗体反应免疫交互和byamagata主导地位.pdf
- crosslinked graft copolymer of methacrylic acid and gelatin as a novel hydrogel with ph-responsiveness properties交联甲基丙烯酸的接枝共聚物凝胶作为一种新型水凝胶和ph-responsiveness属性.pdf
- cross-neutralization potential of native human papillomavirus n-terminal l2 epitopes交叉中和本地人类乳头状瘤病毒n端l2抗原表位的潜力.pdf
- cross-neutralizing antibodies to pandemic 2009 h1n1 and recent seasonal h1n1 influenza a strains influenced by a mutation in hemagglutinin subunit 2cross-neutralizing 2009年大流行h1n1流感病毒的抗体和最近的季节性h1n1流感株血凝素亚基2的突变的影响.pdf
- cross-complementation study of the flagellar type iii export apparatus membrane protein flhbcross-complementation鞭毛的研究类型iii flhb出口装置膜蛋白质.pdf
文档评论（0）