有哪些信誉好的足球投注网站consensus micro rnas governing the switch of dormant tumors to the fast-growing angiogenic phenotype共识微rna调节开关快速增长的休眠肿瘤血管生成表现型.pdfVIP
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consensus micro rnas governing the switch of dormant tumors to the fast-growing angiogenic phenotype共识微rna调节开关快速增长的休眠肿瘤血管生成表现型
Consensus Micro RNAs Governing the Switch of Dormant Tumors to the Fast-Growing Angiogenic Phenotype 1 1 2 3 1 3 Nava Almog *, Lili Ma , Christian Schwager , Bastian G. Brinkmann , Afshin Beheshti , Peter Vajkoczy , 4{ 1 1,2 Judah Folkman , Lynn Hlatky , Amir Abdollahi * 1 Center of Cancer Systems Biology, Steward Research Specialty Projects Corp., St. Elizabeth’s Medical Center, Tufts University School of Medicine, Boston, Massachusetts, United States of America, 2 Molecular and Translational Radiation Oncology, Heidelberg Ion Therapy Center, University of Heidelberg Medical School and ´ National Center for Tumor diseases, German Cancer Research Center, Heidelberg, Germany, 3 Department of Neurosurgery, Charite – Universitaetsmedizin Berlin, Berlin, Germany, 4 Department of Surgery, Harvard Medical School and Vascular Biology Program, Children’s Hospital, Boston, Massachusetts, United States of America Abstract Tumor dormancy refers to a critical stage in cancer development in which tumor cells remain occult for a prolonged period of time until they eventually progress and become clinically apparent. We previously showed that the switch of dormant tumors to fast-growth is angiogenesis dependent and requires a stable transcriptional reprogramming in tumor cells. Considering microRNAs (miRs) as master regulators of transcriptome, we sought to investigate their role in the control of tumor dormancy. We report here the identification of a consensus set of 19 miRs that govern the phenotypic switch of
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