consequences of gestational malaria on birth weight finding the best timeframe for intermittent preventive treatment administration妊娠期疟疾的后果在出生体重发现间歇性预防治疗的最佳时间管理.pdfVIP

Consequences of Gestational Malaria on Birth Weight: Finding the Best Timeframe for Intermittent Preventive Treatment Administration 1,2 1,2 ´ 1,2 1,2 3 Bich-Tram Huynh *, Nadine Fievet , Valerie Briand , Sophie Borgella , Achille Massougbodji , 1,2 1,2 Philippe Deloron , Michel Cot ´ 2 ´ ´ 1 UMR216, Institut de Recherche pour le Developpement, Paris, France, Universite Paris Descartes, Paris, France, 3 UER de Parasitologie, Faculte des Sciences de la ´ ´ Sante, Cotonou, Benin Abstract To investigate the consequences of intermittent preventive treatment (IPTp) timing on birth weight, we pooled data from two studies conducted in Benin between 2005 and 2010: a prospective cohort of 1037 pregnant women and a randomised trial comparing sulfadoxine-pyrimethamine (SP) to mefloquine in 1601 women. A total of 1439 women (752 in the cohort and 687 in the SP arm of the randomised trial) who delivered live singletons were analysed. We showed that an early intake of the first SP dose (4 months of gestation) was associated with a lower risk of LBW compared to a late intake (6–7 months of gestation) (aOR = 0.5 p = 0.01). We also found a borderline increased risk of placental infection when the first SP dose was administered early in pregnancy (aOR = 1.7 p = 0.1). This study is the first to investigate the timing of SP administration during pregnancy. We clearly demonstrated that women who had an early intake of the first SP dose were less at risk of LBW compared to those who had a late intake. Pr