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biological activities of polyphenols from grapes葡萄多酚的生物活性.pdf

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biological activities of polyphenols from grapes葡萄多酚的生物活性

Int. J. Mol. Sci. 2010, 11, 622-646; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Review Biological Activities of Polyphenols from Grapes En-Qin Xia, Gui-Fang Deng, Ya-Jun Guo and Hua-Bin Li * Department of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China; E-Mails: enqinxia@163.com (E.X.); misyfly@163.com (G.D.); guoyajunleo@163.com (Y.G.) * Author to whom correspondence should be addressed; E-Mail: lihuabin@; Tel.: +86-20-8733-2391; Fax: +86-20-8733-0446. Received: 1 December 2009; in revised form: 26 January 2010 / Accepted: 29 January 2010 / Published: 4 February 2010 Abstract: The dietary consumption of grape and its products is associated with a lower incidence of degenerative diseases such as cardiovascular disease and certain types of cancers. Most recent interest has focused on the bioactive phenolic compounds in grape. Anthocyanins, flavanols, flavonols and resveratrol are the most important grape polyphenols because they possess many biological activities, such as antioxidant, cardioprotective, anticancer, anti-inflammation, antiaging and antimicrobial properties. This review summarizes current knowledge on the bioactivities of grape phenolics. The extraction, isolation and identification methods