y1 and y5 receptors are both required for the regulation of food intake and energy homeostasis in micey1和y5受体都是需要调节食物摄入量和能量在老鼠体内平衡.pdfVIP

Y1 and Y5 Receptors Are Both Required for the Regulation of Food Intake and Energy Homeostasis in Mice 1. 1 1 1 1 2 Amy D. Nguyen , Natalie F. Mitchell , Shu Lin , Laurence Macia , Ernie Yulyaningsih , Paul A. Baldock , 2 1 1 3 1,4. Ronaldo F. Enriquez , Lei Zhang , Yan-Chuan Shi , Serge Zolotukhin , Herbert Herzog , 1,5,6 . Amanda Sainsbury * 1 Neuroscience Research Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales, Australia, 2 Bone and Mineral Research Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales, Australia, 3 Division of Cell and Molecular Therapy, University of Florida, Gainesville, Florida, United States of America, 4 Faculty of Medicine, University of New South Wales, Kensington, Sydney, New South Wales, Australia, 5 School of Medical Sciences, University of New South Wales, Kensington, Sydney, New South Wales, Australia, 6 Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia Abstract Neuropeptide Y (NPY) acting in the hypothalamus is one of the most powerful orexigenic agents known. Of the five known Y receptors, hypothalamic Y1 and Y5 have been most strongly implicated in mediating hyperphagic effects. However, knockout of individual Y1 or Y5 receptors induces late-onset obesity – and Y5 receptor knockout also induces hyperphagia, possibly due to redundancy in functions of these genes. Here we show that food intake in mice requires the combined actions of both Y1 and Y5 receptors. Germline Y1Y