有哪些信誉好的足球投注网站yeast bax inhibitor, bxi1p, is an er-localized protein that links the unfolded protein response and programmed cell death in saccharomyces cerevisiaebxi1p酵母伯灵顿抑制剂,是一种er-localized蛋白质链接展开蛋白质反应,在酿酒酵母细胞程序性死亡.pdfVIP
- 1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
yeast bax inhibitor, bxi1p, is an er-localized protein that links the unfolded protein response and programmed cell death in saccharomyces cerevisiaebxi1p酵母伯灵顿抑制剂,是一种er-localized蛋白质链接展开蛋白质反应,在酿酒酵母细胞程序性死亡
Yeast Bax Inhibitor, Bxi1p, Is an ER-Localized Protein That Links the Unfolded Protein Response and Programmed Cell Death in Saccharomyces cerevisiae James Cebulski., Joshua Malouin.¤a, Nathan Pinches.¤b, Vincent Cascio, Nicanor Austriaco* Department of Biology, Providence College, Providence, Rhode Island, United States of America Abstract Bax inhibitor-1 (BI-1) is an anti-apoptotic gene whose expression is upregulated in a wide range of human cancers. Studies in both mammalian and plant cells suggest that the BI-1 protein resides in the endoplasmic reticulum and is involved in the unfolded protein response (UPR) that is triggered by ER stress. It is thought to act via a mechanism involving altered calcium dynamics. In this paper, we provide evidence that the Saccharomyces cerevisiae protein encoded by the open reading frame, YNL305C, is a bona fide homolog for BI-1. First, we confirm that yeast cells from two different strain backgrounds lacking YNL305C, which we have renamed BXI1, are more sensitive to heat-shock induced cell death than wildtype controls even though they have indistinguishable growth rates at 30uC. They are also more susceptible both to ethanol-induced and to glucose-induced programmed cell death. Significantly, we show that Bxi1p-GFP colocalizes with the ER localized protein Sec63p-RFP. We have also discovered that Dbxi1 cells are not only more sensitive to drugs that induce ER stress, but also have a decreased unfolded protein response as measured with a UPRE-lacZ reporter. Finally, we have discovered that deleting BXI1 diminishes the calcium signaling response in response to the accumulation of unfolded proteins in the ER as measured by a calcineurin-dependent CDRE-lacZ reporter. In toto, our data suggests that the Bxi1p, like its metazoan homologs, is an ER-localized protein that links the unfolded protein response and prog
您可能关注的文档
- when one size does not fit all a simple statistical method to deal with across-individual variations of effects当一个大小并不适合所有人一个简单的统计方法来处理各个变化的影响.pdf
- when the genome plays dice circumvention of the spindle assembly checkpoint and near-random chromosome segregation in multipolar cancer cell mitoses当基因组玩骰子的规避主轴装配检查点和随机染色体隔离在多极癌症细胞有丝分裂.pdf
- when the social meets the semantic social semantic web or web 2.5当社会满足语义社会语义web或web 2.5.pdf
- when tuberculosis comes back who develops recurrent tuberculosis in california当肺结核回来发展复发肺结核在加州.pdf
- wheat drought-responsive grain proteome analysis by linear and nonlinear 2-de and maldi-tof mass spectrometry小麦drought-responsive谷物的蛋白质组分析线性和非线性两种和maldi-tof质谱分析.pdf
- which compound to select in lead optimization prospectively validated proteochemometric models guide preclinical development在铅化合物选择优化前瞻性验证proteochemometric模型指导临床前开发.pdf
- when subterranean termites challenge the rules of fungal epizootics当地下白蚁挑战规则的真菌传染病之一.pdf
- whip use by jockeys in a sample of australian thoroughbred races—an observational study鞭子骑士使用澳大利亚纯种马races-an观察性研究的样本.pdf
- whispering to the deaf communication by a frog without external vocal sac or tympanum in noisy environments聋人交流低语,一只青蛙没有外部声囊或鼓膜在嘈杂的环境中.pdf
- white matter atrophy and cognitive dysfunctions in neuromyelitis optica白质在视neuromyelitis萎缩和认知障碍.pdf
- yeast mitochondrial biogenesis a role for the puf rna-binding protein puf3p in mrna localization酵母线粒体生物起源的角色puf rna结合蛋白puf3p mrna本地化.pdf
- y1 and y5 receptors are both required for the regulation of food intake and energy homeostasis in micey1和y5受体都是需要调节食物摄入量和能量在老鼠体内平衡.pdf
- yeast mitochondrial interactosome model metabolon membrane proteins complex involved in the channeling of adpatp该公司膜蛋白的酵母线粒体interactosome模型复杂的adpatp参与引导.pdf
- yeast screens identify the rna polymerase ii ctd and spt5 as relevant targets of brca1 interaction酵母屏幕识别rna聚合酶ii ctd和spt5 brca1互动的相关目标.pdf
- yeast ist2 recruits the endoplasmic reticulum to the plasma membrane and creates a ribosome-free membrane microcompartment酵母ist2新兵的内质网质膜并创建一个microcompartment ribosome-free膜.pdf
- yeast transcription termination factor rtt103 functions in dna damage response酵母转录终止因子rtt103函数在dna损伤反应.pdf
- yersinia enterocolitica serum resistance proteins yada and ail bind the complement regulator c4b-binding protein鼠疫enterocolitica抗血清蛋白质雅达和病痛绑定补充监管机构c4b-binding蛋白质.pdf
- yeast functional genomic screens lead to identification of a role for a bacterial effector in innate immunity regulation酵母功能基因组屏幕导致鉴定细菌的作用在先天免疫调节效应.pdf
- yersinia enterocolitica targets cells of the innate and adaptive immune system by injection of yops in a mouse infection model鼠疫enterocolitica目标细胞的先天和适应性免疫系统注入yops小鼠感染模型.pdf
- yersinia pestis evolution on a small timescale comparison of whole genome sequences from north america鼠疫杆菌全基因组序列的进化在小时间尺度比较来自北美.pdf
文档评论（0）