y chromosomal variation tracks the evolution of mating systems in chimpanzee and bonoboy染色体变异轨迹在黑猩猩和倭黑猩猩交配的进化系统.pdfVIP

Y Chromosomal Variation Tracks the Evolution of Mating Systems in Chimpanzee and Bonobo 1. 1.¤a 1 ¨ 1¤b 1,2 Felix Schaller , Antonio M. Fernandes , Christine Hodler , Claudia Munch , Juan J. Pasantes , 3 1 Wolfram Rietschel , Werner Schempp * 1 Institute of Human Genetics, University of Freiburg, Freiburg, Germany, 2 Department of Biochemistry, Genetics and Immunology, University of Vigo, Vigo, Spain, 3 Wilhelma der zoologisch botanische Garten, Stuttgart, Germany Abstract The male-specific regions of the Y chromosome (MSY) of the human and the chimpanzee (Pan troglodytes) are fully sequenced. The most striking difference is the dramatic rearrangement of large parts of their respective MSYs. These non- recombining regions include ampliconic gene families that are known to be important for male reproduction,and are consequently under significant selective pressure. However, whether the published Y-chromosomal pattern of ampliconic fertility genes is invariable within P. troglodytes is an open but fundamental question pertinent to discussions of the evolutionary fate of the Y chromosome in different primate mating systems. To solve this question we applied fluorescence in situ hybridisation (FISH) of testis-specific expressed ampliconic fertility genes to metaphase Y chromosomes of 17 chimpanzees derived from 11 wild-born males and 16 bonobos representing seven wild-born males. We show that of eleven P. troglodytes Y-chromosomal lines, ten Y-chromosomal variants were detected based on the number a