有哪些信誉好的足球投注网站whole genome sequence analysis of cryptococcus gattii from the pacific northwest reveals unexpected diversity全基因组序列分析的隐球菌gattii从太平洋西北揭示意想不到的多样性.pdfVIP
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whole genome sequence analysis of cryptococcus gattii from the pacific northwest reveals unexpected diversity全基因组序列分析的隐球菌gattii从太平洋西北揭示意想不到的多样性
Whole Genome Sequence Analysis of Cryptococcus gattii from the Pacific Northwest Reveals Unexpected Diversity 1. 1 . 2 2 3 John D. Gillece , James M. Schupp * , S. Arunmozhi Balajee , Julie Harris , Talima Pearson , Yongpan 4 3 5 6 7 1 Yan , Paul Keim , Emilio DeBess , Nicola Marsden-Haug , Ron Wohrle , David M. Engelthaler , Shawn R. Lockhart2 1 Pathogen Genomics Division, Translational Genomics Research Institute, Flagstaff, Arizona, United States of America, 2 Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America, 3 Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona, United States of America, 4 Center for Genetic Epidemiology and Prevention, Van Andel Institute, Grand Rapids, Michigan, United States of America, 5 Oregon State Department of Human Services, Portland, Oregon, United States of America, 6 Washington State Department of Health, Shoreline, Washington, United States of America, 7 Washington State Department of Health, Tumwater, Washington, United States of America Abstract A recent emergence of Cryptococcus gattii in the Pacific Northwest involves strains that fall into three primarily clonal molecular subtypes: VGIIa, VGIIb and VGIIc. Multilocus sequence typing (MLST) and variable number tandem repeat analysis appear to identify little diversity within these molecular subtypes. Given the apparent expansion of these subtypes into new geographic areas and their ability to cause disease in immunocompetent individuals, differentiation of isolates belonging to these subtypes could be very important
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