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Materials 2011, 4, 991-1012; doi:10.3390/ma4060991 OPEN ACCESS materials ISSN 1996-1944 /journal/materials Review Antiviral Activity of Metal-Containing Polymers—Organotin and Cisplatin-Like Polymers Michael R. Roner 1,*, Charles E. Carraher, Jr.2,3, Kimberly Shahi 4 and Girish Barot 5 1 Department of Biology, University of Texas Arlington, Arlington, TX 76019, USA 2 Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL 33431, USA; E-Mail: carraher@ 3 Florida Center for Environmental Studies, Palm Beach Gardens, FL 33410, USA 4 Department of Biological Sciences, University of North Texas, Denton, TX 76203, USA; E-Mail: kimberly.shahi@ 5 Department of Biology, Boston University, Boston, MA 02215, USA; E-Mail: irishbarod@ * Author to whom correspondence should be addressed; E-Mail: roner@; Tel.: +1-817-272-1302. Received: 26 April 2011; in revised form: 19 May 2011 / Accepted: 26 May 2011 / Published: 27 May 2011 Abstract: Polymers containing platinum and to a lesser extent tin, have repeatedly demonstrated antitumor activity in vitro and in vivo against a variety of cell and tumor types. The mechanisms responsible for the antitumor activity include inducing a delay in cell proliferation and sister chromatid exchanges blocking tumor growth. As most DNA and some RNA viruses require, and even induce, infected cells to initiate DNA replication and subsequent cell division, compounds with antitumor activity will very likely also possess antiviral activity. This articl