有哪些信誉好的足球投注网站anxiogenic effects of developmental bisphenol a exposure are associated with gene expression changes in the juvenile rat amygdala and mitigated by soyanxiogenic发展接触双酚a的影响与基因表达变化的幼年大鼠杏仁核和减轻大豆.pdfVIP
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anxiogenic effects of developmental bisphenol a exposure are associated with gene expression changes in the juvenile rat amygdala and mitigated by soyanxiogenic发展接触双酚a的影响与基因表达变化的幼年大鼠杏仁核和减轻大豆
Anxiogenic Effects of Developmental Bisphenol A
Exposure Are Associated with Gene Expression Changes
in the Juvenile Rat Amygdala and Mitigated by Soy
1,2 1,2 1,2 3
Heather B. Patisaul *, Alana W. Sullivan , Meghan E. Radford , Deena M. Walker ,
1,2 4 4 5 3
Heather B. Adewale , Bozena Winnik , Janis L. Coughlin , Brian Buckley , Andrea C. Gore
1 Department of Biology, North Carolina State University, Raleigh, North Carolina, United States of America, 2 Keck Center for Behavioral Sciences, North Carolina State
University, Raleigh, North Carolina, United States of America, 3 Division of Pharmacology and Toxicology, Institute for Neurosciences, and Institute for Cellular and
Molecular Biology, University of Texas at Austin, Austin, Texas, United States of America, 4 Joint Graduate Program of Toxicology, a Joint Institute of Rutgers University and
the University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey, United States of America, 5 Environmental and Occupational Health Science Institute,
Piscataway, New Jersey, United States of America
Abstract
Early life exposure to Bisphenol A (BPA), a component of polycarbonate plastics and epoxy resins, alters sociosexual
behavior in numerous species including humans. The present study focused on the ontogeny of these behavioral effects
beginning in adolescence and assessed the underlying molecular changes in the amygdala. We also explored the mitigating
potential of a soy-rich diet on these endpoints. Wistar rats were exposed to BPA via drinking water (1 mg/L) from gestation
through puberty, and reared on a soy-ba
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