antiplasmodial activities of homogentisic acid derivative protein kinase inhibitors isolated from a vanuatu marine sponge pseudoceratina sp.antiplasmodial活动尿黑酸衍生蛋白激酶抑制剂隔绝瓦努阿图海洋海绵pseudoceratina sp。.pdfVIP
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antiplasmodial activities of homogentisic acid derivative protein kinase inhibitors isolated from a vanuatu marine sponge pseudoceratina sp.antiplasmodial活动尿黑酸衍生蛋白激酶抑制剂隔绝瓦努阿图海洋海绵pseudoceratina sp。
Mar. Drugs 2009, 7, 640-653; doi:10.3390/md7040640
OPEN ACCESS
Marine Drugs
ISSN 1660-3397
/journal/marinedrugs
Article
Antiplasmodial Activities of Homogentisic Acid Derivative
Protein Kinase Inhibitors Isolated from a Vanuatu Marine
Sponge Pseudoceratina sp.
Nicolas Lebouvier 1,*, Valérie Jullian 2,3, Isabelle Desvignes 1, Séverine Maurel 2,3, Arnaud
Parenty 1, Dominique Dorin-Semblat 4,5, Christian Doerig 4,5, Michel Sauvain 2,3 and Dominique
Laurent 2,3
1 Laboratoire de Chimie, Université de la Nouvelle-Calédonie, BP R4, 98851 Nouméa cedex, New
Caledonia; E-Mails: isabelle.desvignes@univ-montp2.fr (I.D.); arnaud.parenty@ (A.P.)
2 Laboratoire de Pharmacochimie des Substances Naturelles et Pharmacophores Redox, Université de
Toulouse, UPS, UMR 152, 118, rte de Narbonne, F-31062 Toulouse cedex 9, France;
E-Mails: jullian@cict.fr (V.J.); chevalleyseverine@yahoo.fr (S.M.); michel.sauvain@ird.fr (M.S.);
dominique.laurent@ird.fr (D.L.)
3 Institut de Recherche pour le Développement (IRD); UMR 152, 118, rte de Narbonne, F-31062
Toulouse cedex 9, France
4 INSERM U609, Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, CH-1015
Lausanne, Switzerland; E-Mails: dominique.dorin@epfl.ch (D.D.-S.);
christian.doerig@epfl.ch (C.D.)
5 Wellcome Centre for Molecular Parasitology, University of Glasgow, Glasgow G12 8TA, Scotland,
UK
* Author to whom correspondence should be addressed; E-Mail: nicolas.lebouvier@univ-nc.nc;
Tel.: +687-260-760; Fax: +687-254-829.
Received: 19 October 2009; in revised form: 17 November 2009/ Accepted: 23 November 2009 /
Published: 23 Novem
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