antiproliferation of hepatoma cell and progression of cell cycle as affected by isoflavone extracts from soybean cake抗肝癌细胞和细胞周期的进展影响异黄酮提取物大豆蛋糕.pdfVIP

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antiproliferation of hepatoma cell and progression of cell cycle as affected by isoflavone extracts from soybean cake抗肝癌细胞和细胞周期的进展影响异黄酮提取物大豆蛋糕.pdf

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antiproliferation of hepatoma cell and progression of cell cycle as affected by isoflavone extracts from soybean cake抗肝癌细胞和细胞周期的进展影响异黄酮提取物大豆蛋糕

Int. J. Mol. Sci. 2007, 8, 1095-1110 International Journal of Molecular Sciences ISSN 1422-0067 © 2007 by MDPI /ijms Full Research Paper Antiproliferation of Hepatoma Cell and Progression of Cell Cycle as Affected by Isoflavone Extracts from Soybean Cake Tsai-Hua Kao, Rwei-Fen S. Huang and Bing-Huei Chen* Department of Nutrition and Food Sciences, Fu Jen University, Taipei 242, Taiwan * Author to whom correspondence should be addressed; E-mail: 002622@.tw; Phone: 886-2 Fax: 886-2 Received: 10 September 2007; in revised form: 30 October 2007 / Accepted: 5 November 2007 / Published: 21 November 2007 Abstract: The objectives of this study were to isolate various isoflavone fractions and extracts from soybean cake by preparative column chromatography and compare them with isoflavone standards with regards to inhibition of HepG2 cancer cell proliferation. Four fractions, including malonylglucoside, glucoside, acetylglucoside and aglycone, and two isoflavone extracts, ISO-1 and ISO-2, were collected for evaluation. MTT test results showed that most treatments were slightly protective against HepG2 cell growth at a low dose of isoflavone (5 and 10 μg/mL). However, at elevated concentration of isoflavone (20-50 μg/mL), both aglycone and acetylglucoside fractions as well as a mixture of isoflavone standards were the most effective in inhibition, demonstrating a p