antiproliferative and antiangiogenic activities of smenospongine, a marine sponge sesquiterpene aminoquinone海洋海绵抗增殖和抗血管新生活动smenospongine倍半萜烯aminoquinone.pdfVIP

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antiproliferative and antiangiogenic activities of smenospongine, a marine sponge sesquiterpene aminoquinone海洋海绵抗增殖和抗血管新生活动smenospongine倍半萜烯aminoquinone.pdf

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antiproliferative and antiangiogenic activities of smenospongine, a marine sponge sesquiterpene aminoquinone海洋海绵抗增殖和抗血管新生活动smenospongine倍半萜烯aminoquinone

Mar. Drugs 2011, 9, 154-161; doi:10.3390/md9020154 OPEN ACCESS Marine Drugs ISSN 1660-3397 /journal/marinedrugs Article Antiproliferative and Antiangiogenic Activities of Smenospongine, a Marine Sponge Sesquiterpene Aminoquinone Dexin Kong 1,2,*, Takao Yamori 2, Motomasa Kobayashi 3 and Hongquan Duan 1 1 School of Pharmaceutical Sciences and Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China; E-Mail: duanhq@ 2 Division of Molecular Pharmacology, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 3-10-6, Ariake, Koto-ku, Tokyo 135-8550, Japan; E-Mail: yamori@jfcr.or.jp 3 Graduate School of Pharmaceutical Sciences, Osaka University, Yamada-oka 1-6, Suita, Osaka 565-0871, Japan; E-Mail: kobayashi@phs.osaka-u.ac.jp * Author to whom correspondence should be addressed; E-Mail: kongdexin@; Tel.: +86-22 Fax: +86-22 Received: 17 December 2010; in revised form: 11 January 2011 / Accepted: 27 January 2011 / Published: 28 January 2011 Abstract: We previously reported that smenospongine, a sesquiterpene aminoquinone isolated from the marine sponge Dactylospongia elegans, showed antiproliferative or cytotoxic activities on leukemia cells. In this study, we investigated the effect of smenospongine on solid tumors. Since angiogenesis is well known to be closely involved in growth and metastasis of solid tumors, the antiangiogenic effect of smenospongine was determined. We found that smenospongine inhibited proliferation, migration and tube