anti-proliferation and anti-invasion effects of diosgenin on gastric cancer bgc-823 cells with hif-1α shrnas防扩散和anti-invasion薯蓣皂苷配基对胃癌bgc - 823细胞的影响与hif-1α成分.pdfVIP
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anti-proliferation and anti-invasion effects of diosgenin on gastric cancer bgc-823 cells with hif-1α shrnas防扩散和anti-invasion薯蓣皂苷配基对胃癌bgc - 823细胞的影响与hif-1α成分
Int. J. Mol. Sci. 2012, 13, 6521-6533; doi:10.3390/ijm
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/journal/ijms
Article
Anti-Proliferation and Anti-Invasion Effects of Diosgenin on
Gastric Cancer BGC-823 Cells with HIF-1α shRNAs
Zhu-Jun Mao 1, Qian-Jue Tang 1, Ci-An Zhang 2, Zhi-Feng Qin 2, Bin Pang 3, Pin-kang Wei 2,*,
Bo Liu 4,* and Yuan-Neng Chou 5
1
Department of Obstetrics and Gynecology, Longhua Hospital Shanghai University of Traditional
Chinese medicine, Shanghai 200032, China; E-Mails: zhujunlina@ (Z.-J.M.);
quinjue75@ (Q.-J.T.)
2
Department of Traditional Chinese medicine, Shanghai Changzheng Hospital, Senond Military
Medical University, Shanghai 200003, China; E-Mails: happydrtcm@ (C.-A.Z.);
qinzf@126.com (Z.-F.Q.)
3 Air Force Center of Aviation Medical Evaluation and Training, Dujiangyan 611833, China;
E-Mail: pangbin88@
4
Cardiovascular Department, Shanghai ChangHai Hospital, Second Military Medical University,
Shanghai 200003, China
5
Shanghai University of Traditional Chinese medicine, Shanghai 201203, China;
E-Mail: john_chou21656@
* Authors to whom correspondence should be addressed; E-Mails: pinkangw@163.com (P.W.);
bobo198207@ (B.L.); Tel./Fax: +86-21-8188-5476 (P.W.).
Received: 22 February 2012; in revised form: 2 April 2012 / Accepted: 9 May 2012 /
Published: 24 May 2012
Abstract: Drug resistance is a major factor for the limited efficacy of chemot
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