有哪些信誉好的足球投注网站analysis of her1 and her7 mutants reveals a spatio temporal separation of the somite clock moduleher1和her7突变体的分析揭示了一个spatio颞体节时钟模块的分离.pdfVIP
- 1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
analysis of her1 and her7 mutants reveals a spatio temporal separation of the somite clock moduleher1和her7突变体的分析揭示了一个spatio颞体节时钟模块的分离
Analysis of her1 and her7 Mutants Reveals a Spatio
Temporal Separation of the Somite Clock Module
1 ¤a 2. ¨ 1. 1¤b
Suma Choorapoikayil * , Bernd Willems , Peter Strohle , Martin Gajewski
1 Institute for Genetics, University to Cologne, Koeln, Germany, 2 Department of Biological Sciences and National University of Singapore Centre for BioImaging Sciences,
National University of Singapore, Singapore, Singapore
Abstract
Somitogenesis is controlled by a genetic network consisting of an oscillator (clock) and a gradient (wavefront). The ‘‘hairy
and Enhancer of Split’’- related (her) genes act downstream of the Delta/Notch (D/N) signaling pathway, and are crucial
components of the segmentation clock. Due to genome duplication events, the zebrafish genome, possesses two gene
copies of the mouse Hes7 homologue: her1 and her7. To better understand the functional consequences of this gene
duplication, and to determine possible independent roles for these two genes during segmentation, two zebrafish mutants
her1hu2124 and her7hu2526 were analyzed. In the course of embryonic development, her1hu2124 mutants exhibit disruption of
the three anterior-most somite borders, whereas her7hu2526 mutants display somite border defects restricted to somites 8 (+/
23) to 17 (+/ 23) along the anterior-posterior axis. Analysis of the molecular defects in her1hu2124 mutants reveals a her1
auto regulatory feedback loop during early somitogenesis that is crucial for correct patterning and independent of her7
oscillation. This feedback loop appears to be restricted to early segmentation, as cyclic her1 expression is restored in
her1hu2124 embryos at later stages of development. Mo
您可能关注的文档
- an actor-based model of social network influence on adolescent body size, screen time, and playing sports概念性模型,社交网络对青少年的影响身体大小、屏幕的时间,和运动.pdf
- an adaptive h-refinement algorithm for local damage models局部损伤模型的自适应h-refinement算法.pdf
- amyloid precursor protein is required for normal function of the rod and cone pathways in the mouse retina淀粉样前体蛋白的正常功能需要鼠标视网膜的视杆细胞和视锥通路.pdf
- an adamtsl2 founder mutation causes musladin-lueke syndrome, a heritable disorder of beagle dogs, featuring stiff skin and joint contracturesadamtsl2创始人的突变会导致musladin-lueke综合症,一个遗传障碍小猎犬的狗,有硬的皮肤和关节挛缩.pdf
- an abundant tissue macrophage population in the adult murine heart with a distinct alternatively-activated macrophage profile人口丰富组织巨噬细胞在成年小鼠心脏明显的替代性活化巨噬细胞.pdf
- an administrative claims model for profiling hospital 30-day mortality rates for pneumonia patients行政索赔模型分析对肺炎病人医院30天死亡率.pdf
- an advanced electron spin resonance (esr) spin-trapping and lc(esr)ms technique for the study of lipid peroxidation一个先进的电子自旋共振(esr)spin-trapping和lc女士(esr)技术,对脂质过氧化的研究.pdf
- an adsorptive transfer technique coupled with brdicka reaction to reveal the importance of metallothionein in chemotherapy with platinum based cytostatics一种吸附传输技术加上brdicka反应揭示金属硫蛋白的重要性与铂化疗抑制细胞生长的基础.pdf
- an afm-based stiffness clamp for dynamic control of rigidity一个afm-based刚度夹动态刚度的控制.pdf
- an agent-based fuzzy collaborative intelligence approach for predicting the price of a dynamic random access memory (dram) product一个基于主体的模糊协同智能方法预测的价格动态随机存取记忆体(dram)产品.pdf
- analysis of intraviral protein-protein interactions of the sars coronavirus orfeome分析intraviral sars冠状病毒orfeome蛋白质-蛋白质之间的关系.pdf
- analysis of jak2 catalytic function by peptide microarrays the role of the jh2 domain and v617f mutation分析jak2催化功能的多肽微阵列jh2的作用域和v617f突变.pdf
- analysis of intracellular state based on controlled 3d nanostructures mediated surface enhanced raman scattering分析基于控制三维纳米结构介导的细胞内状态表面增强拉曼散射.pdf
- analysis of kinase gene expression patterns across 5681 human tissue samples reveals functional genomic taxonomy of the kinome激酶基因表达模式分析5681个人类组织样本显示功能基因组激酶组的分类.pdf
- analysis of mechanisms of t-2 toxin toxicity using yeast dna microarrays分析2毒素毒性的机制使用酵母dna微阵列.pdf
- analysis of imprinted gene expression in normal fertilized and uniparental preimplantation porcine embryos印迹基因表达分析在正常受精和单性生殖的胚胎植入前的猪胚胎.pdf
- analysis of in-vivo lacr-mediated gene repression based on the mechanics of dna looping分析已lacr-mediated基因镇压基于dna循环的机制.pdf
- analysis of marker-defined hnscc subpopulations reveals a dynamic regulation of tumor initiating properties分析marker-defined hnscc亚种群显示了一个动态调节肿瘤启动属性.pdf
- analysis of micro- and nano-structures of the corneal surface of drosophila and its mutants by atomic force microscopy and optical diffraction分析果蝇的角膜表面的微-纳米结构及其突变体通过原子力显微镜和光学衍射.pdf
- analysis of lhcsr3, a protein essential for feedback de-excitation in the green alga chlamydomonas reinhardtiilhcsr3分析,蛋白质必不可少的反馈去激发的绿藻衣藻reinhardtii.pdf
文档评论（0）