有哪些信誉好的足球投注网站antinociceptive and anti-inflammatory activities of the ethanol extract of annona muricata l. leaves in animal modelsantinociceptive乙醇提取物的抗炎活动番荔枝属muricata l .叶子在动物模型.pdfVIP
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antinociceptive and anti-inflammatory activities of the ethanol extract of annona muricata l. leaves in animal modelsantinociceptive乙醇提取物的抗炎活动番荔枝属muricata l .叶子在动物模型
Int. J. Mol. Sci. 2010, 11, 2067-2078; doi:10.3390/ijm
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/journal/ijms
Article
Antinociceptive and Anti-Inflammatory Activities of the Ethanol
Extract of Annona muricata L. Leaves in Animal Models
Orlando Vieira de Sousa 1,*, Glauciemar Del-Vechio Vieira 1, José de Jesus R. G. de Pinho 1,
Célia Hitomi Yamamoto 1 and Maria Silvana Alves 2
1 Departamento Farmacêutico, Faculdade de Farmácia e Bioquímica, Universidade Federal de Juiz de
Fora, Campus Universitário, Martelos, 36036-330, Juiz de Fora, MG, Brazil;
E-Mails: glauciemar@ (G.D.-V.V.); jose.pinho@.br (J.J.R.G.P.);
hytomani@ (C.H.Y.)
2 Departamento de Análises Clínicas, Faculdade de Farmácia e Bioquímica, Universidade Federal de
Juiz de Fora, Campus Universitário, Martelos, 36036-330, Juiz de Fora, MG, Brazil;
E-Mail: alves_ms2005@.br
* Author to whom correspondence should be addressed; E-Mail: orlando.sousa@.br;
Tel.: +55-32-2102-3819; Fax: +55-32-2102-3812.
Received: 2 April 2010; in revised form: 23 April 2010 / Accepted: 27 April 2010 /
Published: 6 May 2010
Abstract: Antinociceptive and anti-inflammatory activities of the ethanol extract from
Annona muricata L. leaves were investigated in animal models. The extract delivered per
oral route (p.o.) reduced the number of abdominal contortions by 14.42% (at a dose of
200 mg/kg) and 41.41% (400 mg/kg). Doses of 200
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