anti-obesity effect of nepetae spica extract in high-fat mice肥胖的影响nepetae穗状花序提取高脂小鼠.pdfVIP

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anti-obesity effect of nepetae spica extract in high-fat mice肥胖的影响nepetae穗状花序提取高脂小鼠.pdf

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anti-obesity effect of nepetae spica extract in high-fat mice肥胖的影响nepetae穗状花序提取高脂小鼠

Agriculture 2012, 2, 204-210; doi:10.3390/agriculture2030204 OPEN ACCESS agriculture ISSN 2077-0472 /journal/agriculture Short Note Anti-Obesity Effect of Nepetae spica Extract in High-Fat Mice Changhyun Roh 1,*, Min-Kyoung Park 1,2,*, Hee-June Shin 1, Insub Kim 1, Jin Kyu Kim 1 and 1 Uhee Jung 1 Division of Biotechnology, Advanced Radiation Technology Institute (ARTI), Korea Atomic Energy Research Institute (KAERI), 1266, Sinjeong-dong, Jeongeup, Jeonbuk 580-185, Korea; E-Mails: hj_shin@kaeri.re.kr (H.-J.S.); Insub@kaeri.re.kr (I.K.); jkkim@kaeri.re.kr (J.K.K.); uhjung@kaeri.re.kr (U.J.) 2 Department of Chemistry, Seoul National University, Gwanak-ro, Gwanak-gu, Seoul 151-747, Korea * Authors to whom correspondence should be addressed; E-Mails: chroh@kaeri.re.kr (C.R.); mkpark@kaeri.re.kr (M.-K.P.); Tel.: +82-63-570-3133 (C.R.); Fax: +82-63-570-3139 (C.R.). Received: 28 May 2012; in revised form: 31 July 2012 / Accepted: 15 August 2012 / Published: 22 August 2012 Abstract: In recent years, obesity is the most common metabolic disease emerging as a global problem especially in developed nations. The discovery of bioactive compounds from natural plant extracts is one possible way to control obesity and prevent or reduce the risks of getting various obesity-related diseases. In this study, we elucidated that Nepetae spica extract significantly reduced the body weight gain induced through feeding a high-fat diet to C57BL/6 mice. The treatment of Nep