anti-neoplastic activity of two flavone isomers derived from gnaphalium elegans and achyrocline bogotensisanti-neoplastic活动两种黄酮异构体来源于鼠线虫和achyrocline bogotensis.pdfVIP

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anti-neoplastic activity of two flavone isomers derived from gnaphalium elegans and achyrocline bogotensisanti-neoplastic活动两种黄酮异构体来源于鼠线虫和achyrocline bogotensis.pdf

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anti-neoplastic activity of two flavone isomers derived from gnaphalium elegans and achyrocline bogotensisanti-neoplastic活动两种黄酮异构体来源于鼠线虫和achyrocline bogotensis

Anti-Neoplastic Activity of Two Flavone Isomers Derived from Gnaphalium elegans and Achyrocline bogotensis 1. 1. 1. 1 Christan M. Thomas , Robert C. Wood, III , Jarrett E. Wyatt , Morgan H. Pendleton , 2 2 3 4 5 Ruben D. Torrenegra , Oscar E. Rodriguez , Sam Harirforoosh , Maria Ballester , Janet Lightner , Koyamangalath Krishnan5, Victoria P. Ramsauer3,5* 1 Bill Gatton College of Pharmacy, East Tennessee State University, Johnson City, Tennessee, United States of America, 2 Universidad de Ciencias Aplicadas y Ambientales, Bogota, Colombia, 3 Department of Pharmaceutical Sciences, Bill Gatton College of Pharmacy, East Tennessee State University, Johnson City, Tennessee, United States of America, 4 Division of Math Science and Technology, Farquhar College of Arts and Sciences, Nova Southeastern University, Fort Lauderdale, Florida, United States of America, 5 Division of Hematology-Oncology, Department of Internal Medicine, James Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, United States of America Abstract Over 4000 flavonoids have been identified so far and among these, many are known to have antitumor activities. The basis of the relationships between chemical structures, type and position of substituent groups and the effects these compounds exert specifically on cancer cells are not completely elucidated. Here we report the differential cytotoxic effects of two flavone isomers on human cancer cells from breast (MCF7, SK-BR-3), colon (Caco-2, HCT116), pancreas (MIA PaCa, Panc 28), and prostate (PC3, LNCaP) that vary in di