antinociceptive action of isolated mitragynine from mitragyna speciosa through activation of opioid receptor systemantinociceptive行动的孤立mitragynine mitragyna叶通过阿片受体的激活系统.pdfVIP
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antinociceptive action of isolated mitragynine from mitragyna speciosa through activation of opioid receptor systemantinociceptive行动的孤立mitragynine mitragyna叶通过阿片受体的激活系统
Int. J. Mol. Sci. 2012, 13, 11427-11442; doi:10.3390/ijms130911427
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/journal/ijms
Article
Antinociceptive Action of Isolated Mitragynine from Mitragyna
Speciosa through Activation of Opioid Receptor System
Abdul Rahman Shamima 1, Sharida Fakurazi 2,3,*, Mohamad Taufik Hidayat 2,
4 2 3
Ithnin Hairuszah , Mohamad Aris Mohd Moklas and Palanisamy Arulselvan
1 Faculty of Pharmacy, Cyberjaya University College of Medical Sciences, 63000 Cyberjaya,
Selangor, Malaysia; E-Mail: alfaqirah_msc@
2 Faculty of Medicine and Health Sciences, Department of Human Anatomy, Universiti Putra Malaysia,
43400 UPM Serdang, Selangor, Malaysia; E-Mails: taufik@.my (M.T.H.);
aris@.my (M.A.M.M.)
3 Institute of Bioscience, Laboratory of Vaccines and Immunotherapeutics, Universiti Putra Malaysia,
43400 UPM Serdang, Selangor, Malaysia; E-Mail: arulbio@
4 Faculty of Medicine and Health Sciences, Department of Pathology, Universiti Putra Malaysia,
43400 UPM Serdang, Selangor, Malaysia; E-Mail: hairusza@.my
* Author to whom correspondence should be addressed; E-Mail: sharida@.my;
Tel.: +603-8947-2331; Fax: +603-8942-2341.
Received: 10 August 2012; in revised form: 27 August 2012 / Accepted: 27 August 2012
Published: 12 September 2012
Abstract: Cannabinoids and opioids systems share numerous pharmacological properties
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