anti-neuroblastoma activity of gold nanorods bound with gd2 monoclonal antibody under near-infrared laser irradiationanti-neuroblastoma活动金纳米棒用近红外激光辐照下阻止gd2单克隆抗体.pdfVIP

Cancers 2011, 3, 227-240; doi:10.3390/cancers3010227 OPEN ACCESS cancers ISSN 2072-6694 /journal/cancers Article Anti-Neuroblastoma Activity of Gold Nanorods Bound with GD2 Monoclonal Antibody under Near-Infrared Laser Irradiation Ching-An Peng 1,* and Chung-Hao Wang 2 1 Department of Chemical Engineering, Michigan Technological University, 1400 Townsend Drive, Houghton, MI 49931, USA 2 Department of Chemical Engineering, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei 10617, Taiwan * Author to whom correspondence should be addressed; E-Mail: cpeng@; Tel.: +1-906-487-2569. Received: 7 December 2010; in revised form: 26 December 2010 / Accepted: 4 January 2011 / Published: 6 January 2011 Abstract: High-risk neuroblastoma is one of the most common deaths in pediatric oncology. Current treatment of this disease involves a coordinated sequence of chemotherapy, surgery, and radiation. Further advances in therapy will require the targeting of tumor cells in a more selective and efficient way so that survival can be improved without substantially increasing toxicity. To achieve tumor-selective delivery, disialoganglioside (GD2) expressed by almost all neuroblastoma tumors represents a potential molecular target that can be exploited for tumor-selective delivery. In this study, GD2 monoclonal antibody (anti-GD2) was conjugated to gold nanorods (GNRs) which are one of ani