antinociceptive and anti-inflammatory effects of ethanolic extracts of glycine max (l.) merr and rhynchosia nulubilis seedsantinociceptive和ethanolic提取物的抗炎作用大豆(l).pdfVIP
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antinociceptive and anti-inflammatory effects of ethanolic extracts of glycine max (l.) merr and rhynchosia nulubilis seedsantinociceptive和ethanolic提取物的抗炎作用大豆(l)
Int. J. Mol. Sci. 2009, 10, 4742-4753; doi:10.3390/ijm
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/journal/ijms
Article
Antinociceptive and Anti-Inflammatory Effects of Ethanolic
Extracts of Glycine max (L.) Merr and Rhynchosia nulubilis
Seeds
Joo Hyuk Yim 1, Ok-Hwan Lee 2,*, Ung-Kyu Choi 3 and Young-Chan Kim 1,*
1 Korea Food Research Institute, Seongnam, Kyonggi, 463-746, Korea;
E-Mail: jlunar@ (J.H.Y.)
2 Department of Biomedical Science, CHA University, Seongnam, Kyonggi, 463-836, Korea
3 Pohang Center for Evaluation of Biomaterials, Pohang 790-834, Korea;
E-Mail: cuk8272@ (U.-K.C.)
* Authors to whom correspondence should be addressed; E-Mails: yckim@kfri.re.kr (Y.C.K.);
loh99@ (O.H.L.); Tel.: +82-31-780-9145 (Y.C.K.); +82-31-725-8383 (O.H.L.);
Fax: +82-31-780-9312 (Y.C.K.); +82-31-725-8350 (O.H.L.).
Received: 11 October 2009; in revised form: 2 November 2009 / Accepted: 4 November 2009 /
Published: 4 November 2009
Abstract: The aim of this study was to assess the in vivo potential of ethanolic extracts of
Glycine max (L.) Merr. (SoRiTae) and Rhynchosia nulubilis (Yak-Kong) seeds as natural
anti-nociceptive and anti-inflammatory agents. To assess the anti-nociceptive and anti-
inflammatory potential, the ethanolic extracts of SoRiTae and Yak-Kong seeds were tested
in arachidonic acid-induced ear edema, carrageenan induced paw edema, formalin-induced
licking time, acetic acid induced writhing
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