antinociceptive and anti-inflammatory effects of ethanolic extracts of glycine max (l.) merr and rhynchosia nulubilis seedsantinociceptive和ethanolic提取物的抗炎作用大豆(l).pdfVIP

antinociceptive and anti-inflammatory effects of ethanolic extracts of glycine max (l.) merr and rhynchosia nulubilis seedsantinociceptive和ethanolic提取物的抗炎作用大豆(l).pdf

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antinociceptive and anti-inflammatory effects of ethanolic extracts of glycine max (l.) merr and rhynchosia nulubilis seedsantinociceptive和ethanolic提取物的抗炎作用大豆(l)

Int. J. Mol. Sci. 2009, 10, 4742-4753; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article Antinociceptive and Anti-Inflammatory Effects of Ethanolic Extracts of Glycine max (L.) Merr and Rhynchosia nulubilis Seeds Joo Hyuk Yim 1, Ok-Hwan Lee 2,*, Ung-Kyu Choi 3 and Young-Chan Kim 1,* 1 Korea Food Research Institute, Seongnam, Kyonggi, 463-746, Korea; E-Mail: jlunar@ (J.H.Y.) 2 Department of Biomedical Science, CHA University, Seongnam, Kyonggi, 463-836, Korea 3 Pohang Center for Evaluation of Biomaterials, Pohang 790-834, Korea; E-Mail: cuk8272@ (U.-K.C.) * Authors to whom correspondence should be addressed; E-Mails: yckim@kfri.re.kr (Y.C.K.); loh99@ (O.H.L.); Tel.: +82-31-780-9145 (Y.C.K.); +82-31-725-8383 (O.H.L.); Fax: +82-31-780-9312 (Y.C.K.); +82-31-725-8350 (O.H.L.). Received: 11 October 2009; in revised form: 2 November 2009 / Accepted: 4 November 2009 / Published: 4 November 2009 Abstract: The aim of this study was to assess the in vivo potential of ethanolic extracts of Glycine max (L.) Merr. (SoRiTae) and Rhynchosia nulubilis (Yak-Kong) seeds as natural anti-nociceptive and anti-inflammatory agents. To assess the anti-nociceptive and anti- inflammatory potential, the ethanolic extracts of SoRiTae and Yak-Kong seeds were tested in arachidonic acid-induced ear edema, carrageenan induced paw edema, formalin-induced licking time, acetic acid induced writhing

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