anti-hpv16 e2 protein t-cell responses and viral control in women with usual vulvar intraepithelial neoplasia and their healthy partnersanti-hpv16 e2蛋白t细胞反应和病毒控制在女性常见的外阴上皮内瘤及其健康的伙伴.pdfVIP
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anti-hpv16 e2 protein t-cell responses and viral control in women with usual vulvar intraepithelial neoplasia and their healthy partnersanti-hpv16 e2蛋白t细胞反应和病毒控制在女性常见的外阴上皮内瘤及其健康的伙伴
Anti-HPV16 E2 Protein T-Cell Responses and Viral Control
in Women with Usual Vulvar Intraepithelial Neoplasia
and Their Healthy Partners
1,2,3 1,2 3,5 3 3,5
Simon Jacobelli *, Fedoua Sanaa , Micheline Moyal-Barracco , Monique Pelisse , Sophie Berville ,
1,2 1,2,3 1,2 ´ ´ 1,2
Pascale Villefroy , Marie Odile North , Suzanne Figueiredo , Benedicte Charmeteau ,
5,6 3 4 ´4 3
Thierry Clerici , Franc¸oise Plantier , Franc¸oise Arnold , Antoine Touze , Nicolas Dupin , Marie-
1,2,3 ´ 1,2 ´ 1,2 1,2,5,6
Franc¸oise Avril , Jean-Gerard Guillet , Remi Cheynier , Isabelle Bourgault-Villada
´ ˆ
1 Institut Cochin, Universite Paris Descartes, CNRS (UMR 8104), Paris, France, 2 INSERM, U1016, Paris, France, 3 AP-HP, Hopital Cochin, Paris, France, 4 INSERM, U618, Tours,
ˆ ´
France, 5 AP-HP, Hopital Ambroise Pare, Boulogne Billancourt, France, 6 UVSQ, Versailles, France
Abstract
T-cell responses (proliferation, intracellular cytokine synthesis and IFNc ELISPOT) against human papillomavirus 16 (HPV16)
E2 peptides were tested during 18 months in a longitudinal study in eight women presenting w
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