有哪些信誉好的足球投注网站an unbiased systems genetics approach to mapping genetic loci modulating susceptibility to severe streptococcal sepsis一个公正的系统遗传学的方法来映射遗传位点调制链球菌脓毒症易感性严重.pdfVIP
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an unbiased systems genetics approach to mapping genetic loci modulating susceptibility to severe streptococcal sepsis一个公正的系统遗传学的方法来映射遗传位点调制链球菌脓毒症易感性严重
An Unbiased Systems Genetics Approach to Mapping
Genetic Loci Modulating Susceptibility to Severe
Streptococcal Sepsis
1,2,3 2,4 1,2,3 3 2 2
Nourtan F. Abdeltawab , Ramy K. Aziz , Rita Kansal , Sarah L. Rowe , Yin Su , Lidia Gardner ,
Charity Brannen2, Mohammed M. Nooh1,2,3,5, Ramy R. Attia1,2,3, Hossam A. Abdelsamed1,2,3,5, William L.
6 7 7 1,2,3,5
Taylor , Lu Lu , Robert W. Williams , Malak Kotb *
1 Mid-South Center for Biodefense and Security, The University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, 2 Department of
Ophthalmology, The University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, 3 VA Medical Center, Memphis, Tennessee, United
States of America, 4 College of Pharmacy, Cairo University, Giza, Egypt, 5 Department of Molecular Sciences, The University of Tennessee Health Science Center, Memphis,
Tennessee, United States of America, 6 Molecular Resource Center, The University of Tennessee Health Science Center, Memphis, Tennessee, United States of America,
7 Department of Anatomy and Neurobiology, The University of Tennessee Health Science Center, Memphis, Tennessee, United States of America
Abstract
Striking individual differences in severity of group A streptococcal (GAS) sepsis have been noted, even among patients
infected with the same bacterial strain. We had provided evidence that HLA class II allelic variation contributes significantly
to differences in systemic disease severity by modulating host responses to streptococcal superantigens. Inasmuch as the
bacteria produce additional virulence factors that participate in the pathogen
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