altered expression of signaling genes in jurkat cells upon fty720 induced apoptosis改变jurkat细胞信号传导基因的表达在fty720诱导细胞凋亡.pdfVIP
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altered expression of signaling genes in jurkat cells upon fty720 induced apoptosis改变jurkat细胞信号传导基因的表达在fty720诱导细胞凋亡
Int. J. Mol. Sci. 2010, 11, 3087-3105; doi:10.3390/ijm
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/journal/ijms
Article
Altered Expression of Signaling Genes in Jurkat Cells upon
FTY720 Induced Apoptosis
Fang Wang 1,†, Wenfeng Tan 2,†, Dunming Guo 3, Xiaomin Zhu 4, Keqing Qian 5 and
Shaoheng He 4,*
1 The Lab of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing
210029, China; E-Mail: fangwang7608@263.net
2 Department of Rheumatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing
210029, China; E-Mail: tanwenfeng2005@126.com
3 Department of Orthopaedics, the First Affiliated Hospital of Nanjing Medical University, Nanjing
210029, China; E-Mail: jbjs3003@
4 The Clinical Experimental Center, the First Affiliated Hospital of Nanjing Medical University,
Nanjing 210029, China; E-Mail: zhuxiaomin1226@126.com
5 Department of Oncology, the Second Changzhou People’s Hospital, Affiliated to Nanjing Medical
University, Changzhou 213003, China; E-Mail: cucu.2007@163.com
† These authors contributed equally to this work.
* Author to whom correspondence should be addressed; E-Mail: fang.wang2009@;
Tel.: +86-25-837-166-02; Fax: +86-25-837-166-02.
Received: 7 August 2010; in revised form: 23 August 2010 / Accepted: 24 August 2010 /
Published: 2 September 2010
Abstract: FTY720, a novel immunosuppressant, has a marked activity in decreasing
peripheral blood T lymphocytes
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