altered insulin receptor signalling and β-cell cycle dynamics in type 2 diabetes mellitus改变胰岛素受体信号在2型糖尿病和β-cell循环动力学.pdfVIP

Altered Insulin Receptor Signalling and b-Cell Cycle Dynamics in Type 2 Diabetes Mellitus 1 . 2. 3. 4 2 Franco Folli * , Terumasa Okada , Carla Perego , Jenny Gunton , Chong Wee Liew , Masaru 2 3 5 5 6 6 Akiyama , Anna D’Amico , Stefano La Rosa , Claudia Placidi , Roberto Lupi , Piero Marchetti , Giorgio 7 8 3 2 Sesti , Marc Hellerstein , Lucia Perego , Rohit N. Kulkarni * 1 Division of Diabetes, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, United States of America, 2 Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, 3 Department of Molecular Science Applied to ` Biosystems, Universita degli Studi di Milano, Milan, Italy, 4 Garvan Institute of Medical Research, Sydney, Australia, 5 Department of Pathology, Ospedale di Circolo and Department of Human Morphology, University of Insubria, Varese, Italy, 6 Division of Endocrinology, University of Pisa, Pisa, Italy, 7 Department of Clinical and Experimental Medicine, University Magna Graecia of Catanzaro, Catanzaro, Italy, 8 Department of Nutritional Sciences and Toxicology, University of California, Berkeley, California, United States of America Abstract Insulin resistance, reduced b-cell mass, and hyperglucagonemia are consistent features in type 2 diabetes mellitus (T2DM). We used pancreas and islets from humans with T2DM to examine the regulation of insulin signaling and cell-cycle control of