有哪些信誉好的足球投注网站adherence to combination prophylaxis for prevention of mother-to-child-transmission of hiv in tanzania坚持在坦桑尼亚联合预防预防艾滋病病毒的母婴传播.pdfVIP
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Adherence to Combination Prophylaxis for Prevention of
Mother-to-Child-Transmission of HIV in Tanzania
1 2 1 3 1 1
Inga Kirsten , Julius Sewangi , Andrea Kunz , Festo Dugange , Judith Ziske , Brigitte Jordan-Harder ,
1 1
Gundel Harms , Stefanie Theuring *
´ ¨
1 Institute of Tropical Medicine and International Health, Charite-Universitatsmedizin Berlin, Berlin, Germany, 2 Regional AIDS Control Program Mbeya Region, Ministry of
Health and Social Welfare, Dar es Salaam, Tanzania, 3 Kyela District Hospital, Ministry of Health and Social Welfare, Dar es Salaam, Tanzania
Abstract
Background: Since 2008, Tanzanian guidelines for prevention of mother-to-child-transmission of HIV (PMTCT) recommend
combination regimen for mother and infant starting in gestational week 28. Combination prophylaxis is assumed to be
more effective and less prone to resistance formation compared to single-drug interventions, but the required continuous
collection and intake of drugs might pose a challenge on adherence especially in peripheral resource-limited settings. This
study aimed at analyzing adherence to combination prophylaxis under field conditions in a rural health facility in Kyela,
Tanzania.
Methods and Findings: A cohort of 122 pregnant women willing to start combination prophylaxis in Kyela District Hospital
was enrolled in an observational study. Risk factors for decline of prophylaxis were determined, and adherence levels before,
during and after delivery were calculated. In multivariate analysis, identified risk factors for declining pre-delivery
prophylaxis included maternal age below 24 yea
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