adipocytokines and cd34+ progenitor cells in alzheimers diseaseadipocytokines和cd34 +祖细胞在阿尔茨海默氏症.pdfVIP
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Adipocytokines and CD34+ Progenitor Cells in
Alzheimer’s Disease
1,2 ¨ 3 1 1 3
Boris Bigalke , Brigitte Schreitmuller , Kateryna Sopova , Angela Paul , Elke Stransky , Meinrad
1 1 . 3 .
Gawaz , Konstantinos Stellos * , Christoph Laske *
¨ ¨ ¨
1 Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard-Karls-Universitat Tubingen, Tubingen, Germany, 2 Division of Imaging Sciences, School of
¨ ¨
Medicine, King’s College London, The Rayne Institute, London, United Kingdom, 3 Department of Psychiatry and Psychotherapy, University of Tubingen, Tubingen,
Germany
Abstract
Background: Alzheimer’s disease (AD) and atherosclerosis share common vascular risk factors such as arterial hypertension
and hypercholesterolemia. Adipocytokines and CD34+ progenitor cells are associated with the progression and prognosis of
atherosclerotic diseases. Their role in AD is not adequately elucidated.
Methods and Findings: In the present study, we measured in 41 patients with early AD and 37 age- and weight-matched
healthy controls blood concentrations of adiponectin and leptin by enzyme linked immunoabsorbent assay and of CD34+
progenitor cells using flow cytometry. We found significantly lower plasma levels of leptin in AD patients compared with the
controls, whereas plasma levels of adiponectin did not show an
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