absent or low rate of adult neurogenesis in the hippocampus of bats (chiroptera)缺失或低的成人海马神经发生的蝙蝠(翼手目).pdfVIP

Absent or Low Rate of Adult Neurogenesis in the Hippocampus of Bats (Chiroptera) 1 1 2¤ 1 Irmgard Amrein , Dina K. N. Dechmann , York Winter , Hans-Peter Lipp * 1 University of Zurich, Institute of Anatomy, Division of Neuroanatomy and Behavior, Zurich, Switzerland, 2 Department of Biology, University of Munich, Munich, Germany Bats are the only flying mammals and have well developed navigation abilities for 3D-space. Even bats with comparatively small home ranges cover much larger territories than rodents, and long-distance migration by some species is unique among small mammals. Adult proliferation of neurons, i.e., adult neurogenesis, in the dentate gyrus of rodents is thought to play an important role in spatial memory and learning, as indicated by lesion studies and recordings of neurons active during spatial behavior. Assuming a role of adult neurogenesis in hippocampal function, one might expect high levels of adult neurogenesis in bats, particularly among fruit- and nectar-eating bats in need of excellent spatial working memory. The dentate gyrus of 12 tropical bat species was examined immunohistochemically, using multiple antibodies against proteins specific for proliferating cells (Ki-67, MCM2), and migrating and differentiating neurons (Doublecortin, NeuroD). Our data show a complete lack of hippocampal neurogenesis in nine of the species (Glossophaga soricina, Carollia perspicillata, Phyllostomus discolor, Nycteris macrotis, Nycteris thebaica, Hipposideros cyclops, Neoromicia rendalli, Pipistrellus guineensis, and Scotophilus leucogaster), while it was present at low levels in three species (Chaerephon pumila, Mops condylurus and Hipposideros caffer). Although not all antigens were recognized in all species, proliferation activity in the subventricular zone and rostral migratory stream was found in all species, c