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a study of nuclear transcription factor-kappa b in childhood autism研究儿童孤独症的核转录factor-kappa b
A Study of Nuclear Transcription Factor-Kappa B in
Childhood Autism
1 2 1 3 1
Usha S. Naik , Charitha Gangadharan , Kanakalatha Abbagani , Balakrishna Nagalla , Niranjan Dasari ,
Sunil K. Manna2*
1 Department of Psychiatry, Osmania Medical College, Hyderabad, India, 2 Laboratory of Immunology, Centre for DNA Fingerprinting and Diagnostics, Nampally,
Hyderabad, India, 3 National Institute of Nutrition, Hyderabad, India
Abstract
Background: Several children with autism show regression in language and social development while maintaining normal
motor milestones. A clear period of normal development followed by regression and subsequent improvement with
treatment, suggests a multifactorial etiology. The role of inflammation in autism is now a major area of study. Viral and
bacterial infections, hypoxia, or medication could affect both foetus and infant. These stressors could upregulate
transcription factors like nuclear factor kappa B (NF-kB), a master switch for many genes including some implicated in
autism like tumor necrosis factor (TNF). On this hypothesis, it was proposed to determine NF-kB in children with autism.
Methods: Peripheral blood samples of 67 children with autism and 29 control children were evaluated for NF-kB using
electrophoretic mobility shift assay (EMSA). A phosphor imaging technique was used to quantify values. The fold increase
over the control sample was calculated and statistical analysis was carried out using SPSS 15.
Results: We have noted significant increase in NF-kB DNA binding activity in peripheral blood samples of children with
autism. When the fold increase of NF-kB in cases (n = 67) was compared
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