第二十七章 调血脂药与抗动脉粥样硬化药（The twenty-seventh chapter is lipid-lowering drugs and anti atherosclerosis drugs）.docVIP

第二十七章 调血脂药与抗动脉粥样硬化药（The twenty-seventh chapter is lipid-lowering drugs and anti atherosclerosis drugs） The twenty-seventh chapter is lipid-lowering drugs and anti atherosclerosis drugs Outline requirements 1, to master the classification and representative drugs of blood lipid regulating drugs, the pharmacological effects, mechanism of action, clinical application and adverse reactions of HMG - CoA reductase inhibitor, probucol, probucol and probucol. 2, familiar with: nicotinic acid, polyene fatty acids, phenoxy acids, antioxidants, anti atherosclerosis effect. 3. To understand the relationship between blood lipid and atherosclerosis, and to protect the pharmacological effects of sulfated polysaccharides from arterial endothelium. Section 1 lipid-lowering drugs, a drug that reduces TC and LDL (I) statins Hydroxymethyl coenzyme a coenzyme A (3-hydroxy-3-, methylglutaryl, CoA, HMG-CoA) reductase inhibitors Lovastatin (lovastatin) Methylated derivatives of simvastatin (simvastatin) lovastatin Pravastatin (pravastatin), an active metabolite of atorvastatin Fluvastatin (fluvastatin) Atorvastatin (atorvastatin) A drug that reduces TC and LDL HMG-CoA reductase is a rate limiting enzyme in the synthesis of cholesterol; The chemical structure is very similar to the statin chemical structure in open loop and HMG- hydroxy acid CoA; therefore, in the early stage of cholesterol synthesis, inhibitedthe HMG-CoA reductase; inhibition of cholesterol synthesis of hepatocytes, cholesterol reducing. (I) statins [pharmacological effects] 1 Effect and mechanism of blood lipid regulation Statins have an obvious lipid-lowering effect To reduce the effect of the strongest ldl-c, TC times The effect of lowering TG is very weak The effect of regulating blood lipid was dose-dependent, and the effect was obvious at 2 weeks, reaching the peak at 4~6 weeks HDL - C increased slightly. 2, non lipid-lowering effect 1, improve the vascular endothelial function and increase the reactivity of the vasc